Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub

Summary for 6HPR

DescriptorBaculoviral IAP repeat-containing protein 2, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ... (5 entities in total)
Functional Keywordsubiquitin, e3, ciap1, ubch5b, ubiquitin ligase, ligase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight42062.09
Patel, A.,Huang, D.T. (deposition date: 2018-09-21, release date: 2018-12-12, Last modification date: 2019-07-10)
Primary citation
Patel, A.,Sibbet, G.J.,Huang, D.T.
Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex.
J. Biol. Chem., 294:1240-1249, 2019
PubMed: 30523153 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.006045
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19710 1.0% 2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution