6HPR

Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Baculoviral IAP repeat-containing protein 2	polymer	65	7305.7	1	UniProt (Q13490) Pfam (PF13920)	Homo sapiens (Human)	Cellular inhibitor of apoptosis 1,C-IAP1,IAP homolog B,Inhibitor of apoptosis protein 2,hIAP2,RING finger protein 48,RING-type E3 ubiquitin transferase BIRC2,TNFR2-TRAF-signaling complex protein 2
2	B, D (B, D)	Polyubiquitin-B	polymer	81	8922.1	2	UniProt (P0CG47) Pfam (PF00240)	Homo sapiens (Human)
3	C (C)	Ubiquitin-conjugating enzyme E2 D2	polymer	147	16781.3	1	UniProt (P62837) Pfam (PF00179)	Homo sapiens (Human)	(E3-independent) E2 ubiquitin-conjugating enzyme D2,E2 ubiquitin-conjugating enzyme D2,Ubiquitin carrier protein D2,Ubiquitin-conjugating enzyme E2(17)KB 2,Ubiquitin-conjugating enzyme E2-17 kDa 2,Ubiquitin-protein ligase D2,p53-regulated ubiquitin-conjugating enzyme 1
4	E, F (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	G, H, I, J (A, B, C, D)	water	water		18.0	222	Chemie (HOH)

Sequence modifications

A: 556 - 618 (UniProt: Q13490)

PDB	External Database	Details
Gly 554	-	expression tag
Ser 555	-	expression tag

B, D: -2 - 76 (UniProt: P0CG47)

PDB	External Database	Details
Gly -4	-	expression tag
Ser -3	-	expression tag
Ser 0	-	insertion

C: 1 - 147 (UniProt: P62837)

PDB	External Database	Details
Lys 85	Cys 85	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	41931.3
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	42062.1

*Water molecules are not included.