6HPR
Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Baculoviral IAP repeat-containing protein 2 | polymer | 65 | 7305.7 | 1 | UniProt (Q13490) Pfam (PF13920) In PDB | Homo sapiens (Human) | Cellular inhibitor of apoptosis 1,C-IAP1,IAP homolog B,Inhibitor of apoptosis protein 2,hIAP2,RING finger protein 48,RING-type E3 ubiquitin transferase BIRC2,TNFR2-TRAF-signaling complex protein 2 |
2 | B, D | Polyubiquitin-B | polymer | 81 | 8922.1 | 2 | UniProt (P0CG47) Pfam (PF00240) In PDB | Homo sapiens (Human) | |
3 | C | Ubiquitin-conjugating enzyme E2 D2 | polymer | 147 | 16781.3 | 1 | UniProt (P62837) Pfam (PF00179) In PDB | Homo sapiens (Human) | (E3-independent) E2 ubiquitin-conjugating enzyme D2,E2 ubiquitin-conjugating enzyme D2,Ubiquitin carrier protein D2,Ubiquitin-conjugating enzyme E2(17)KB 2,Ubiquitin-conjugating enzyme E2-17 kDa 2,Ubiquitin-protein ligase D2,p53-regulated ubiquitin-conjugating enzyme 1 |
4 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A: 556 - 618 (UniProt: Q13490)
B, D: -2 - 76 (UniProt: P0CG47)
C: 1 - 147 (UniProt: P62837)
PDB | External Database | Details |
---|---|---|
Gly 554 | - | expression tag |
Ser 555 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Ser -3 | - | expression tag |
Ser 0 | - | insertion |
PDB | External Database | Details |
---|---|---|
Lys 85 | Cys 85 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 41931.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 130.8 | |
All* | Total formula weight | 42062.1 |