7OJX
E2 UBE2K covalently linked to donor Ub, acceptor di-Ub, and RING E3 primed for K48-linked Ub chain synthesis
Summary for 7OJX
Entry DOI | 10.2210/pdb7ojx/pdb |
Descriptor | E3 ubiquitin-protein ligase RNF38, Ubiquitin-conjugating enzyme E2 K, Polyubiquitin-B, ... (8 entities in total) |
Functional Keywords | ligase, ubiquitin, ring e3, e2 |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 57992.73 |
Authors | Majorek, K.A.,Nakasone, M.A.,Huang, D.T. (deposition date: 2021-05-17, release date: 2022-01-12, Last modification date: 2024-01-31) |
Primary citation | Nakasone, M.A.,Majorek, K.A.,Gabrielsen, M.,Sibbet, G.J.,Smith, B.O.,Huang, D.T. Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension. Nat.Chem.Biol., 18:422-431, 2022 Cited by PubMed: 35027744DOI: 10.1038/s41589-021-00952-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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