7OJX

E2 UBE2K covalently linked to donor Ub, acceptor di-Ub, and RING E3 primed for K48-linked Ub chain synthesis

Summary for 7OJX

Entry DOI	10.2210/pdb7ojx/pdb
Descriptor	E3 ubiquitin-protein ligase RNF38, Ubiquitin-conjugating enzyme E2 K, Polyubiquitin-B, ... (8 entities in total)
Functional Keywords	ligase, ubiquitin, ring e3, e2
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	57992.73
Authors	Majorek, K.A.,Nakasone, M.A.,Huang, D.T. (deposition date: 2021-05-17, release date: 2022-01-12, Last modification date: 2024-01-31)
Primary citation	Nakasone, M.A.,Majorek, K.A.,Gabrielsen, M.,Sibbet, G.J.,Smith, B.O.,Huang, D.T. Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension. Nat.Chem.Biol., 18:422-431, 2022 Cited by PubMed: 35027744 DOI: 10.1038/s41589-021-00952-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation