Author results

2DRP
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THE CRYSTAL STRUCTURE OF A TWO ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER/DNA RECOGNITION
Descriptor:DNA (5'-D(*CP*TP*AP*AP*TP*AP*AP*GP*GP*AP*TP*AP*AP*CP*GP*TP*C P*CP*G)-3'), DNA (5'-D(*TP*CP*GP*GP*AP*CP*GP*TP*TP*AP*TP*CP*CP*TP*TP*AP*T P*TP*A)-3'), PROTEIN (TRAMTRACK DNA-BINDING DOMAIN), ...
Authors:Fairall, L., Schwabe, J.W.R., Chapman, L., Finch, J.T., Rhodes, D.
Deposit date:1994-06-06
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition.
Nature, 366, 1993
1H6O
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DIMERISATION DOMAIN FROM HUMAN TRF1
Descriptor:TELOMERIC REPEAT BINDING FACTOR 1
Authors:Fairall, L., Chapman, L., Rhodes, D.
Deposit date:2001-06-20
Release date:2001-09-05
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.
Mol.Cell, 8, 2001
1H6P
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DIMERISTION DOMAIN FROM HUMAN TRF2
Descriptor:TELOMERIC REPEAT BINDING FACTOR 2, MAGNESIUM ION
Authors:Chapman, L., Fairall, L., Rhodes, D.
Deposit date:2001-06-20
Release date:2001-09-05
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the Trfh Dimerization Domain of the Human Telomere Proteins Trf1 and Trf2
Mol.Cell, 8, 2001
2YHN
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THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENT DEGRADATION OF THE LDL RECEPTOR
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE MYLIP, ZINC ION
Authors:Fairall, L., Goult, B.T., Millard, C.J., Tontonoz, P., Schwabe, J.W.R.
Deposit date:2011-05-04
Release date:2011-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Idol-Ube2D Complex Mediates Sterol-Dependent Degradation of the Ldl Receptor.
Genes Dev., 25, 2011
2YHO
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THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENT DEGRADATION OF THE LDL RECEPTOR
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE MYLIP, UBIQUITIN-CONJUGATING ENZYME E2 D1, ZINC ION, ...
Authors:Fairall, L., Goult, B.T., Millard, C.J., Tontonoz, P., Schwabe, J.W.R.
Deposit date:2011-05-04
Release date:2011-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Idol-Ube2D Complex Mediates Sterol-Dependent Degradation of the Ldl Receptor.
Genes Dev., 25, 2011
6GQF
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THE STRUCTURE OF MOUSE ASTERA (GRAMD1A) WITH 25-HYDROXY CHOLESTEROL
Descriptor:GRAM domain-containing protein 1A, 25-HYDROXYCHOLESTEROL, GLYCEROL
Authors:Fairall, L., Gurnett, J.E., Vashi, D., Sandhu, J., Tontonoz, P., Schwabe, J.W.R.
Deposit date:2018-06-07
Release date:2018-09-26
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.
Cell, 175, 2018
6G16
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STRUCTURE OF THE HUMAN RBBP4:MTA1(464-546) COMPLEX SHOWING LOOP EXCHANGE
Descriptor:Histone-binding protein RBBP4, Metastasis-associated protein MTA1
Authors:Millard, C.J., Varma, N., Fairall, L., Schwabe, J.W.R.
Deposit date:2018-03-20
Release date:2018-06-13
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structure of the core NuRD repression complex provides insights into its interaction with chromatin.
Elife, 5, 2016
2VSR
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HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 9-(S)-HODE
Descriptor:PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
Authors:Itoh, T., Fairall, L., Schwabe, J.W.R.
Deposit date:2008-04-29
Release date:2008-08-19
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VST
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HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 13-(S)-HODE
Descriptor:PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
Authors:Itoh, T., Fairall, L., Schwabe, J.W.R.
Deposit date:2008-04-29
Release date:2008-08-19
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VV0
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HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH DHA
Descriptor:PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID
Authors:Itoh, T., Fairall, L., Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VV1
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HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 4-HDHA
Descriptor:PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid
Authors:Itoh, T., Fairall, L., Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VV2
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HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 5-HEPA
Descriptor:PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
Authors:Itoh, T., Fairall, L., Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VV3
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HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 4-OXODHA
Descriptor:PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (6E,10Z,13Z,16Z,19Z)-4-oxodocosa-6,10,13,16,19-pentaenoic acid
Authors:Itoh, T., Fairall, L., Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Basis for the Activation of Ppargamma by Oxidized Fatty Acids.
Nat.Struct.Mol.Biol., 15, 2008
2VV4
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HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 6-OXOOTE
Descriptor:PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid, (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid
Authors:Itoh, T., Fairall, L., Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2XTC
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STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN
Descriptor:F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
Authors:Oberoi, J., Fairall, L., Watson, P.J., Greenwood, J.A., Schwabe, J.W.R.
Deposit date:2010-10-06
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery.
Nat.Struct.Mol.Biol., 18, 2011
2XTD
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STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN
Descriptor:TBL1 F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
Authors:Oberoi, J., Fairall, L., Watson, P.J., Greenwood, J.A., Schwabe, J.W.R.
Deposit date:2010-10-06
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery.
Nat.Struct.Mol.Biol., 18, 2011
2XTE
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STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN
Descriptor:F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
Authors:Oberoi, J., Fairall, L., Watson, P.J., Greenwood, J.A., Schwabe, J.W.R.
Deposit date:2010-10-06
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery.
Nat.Struct.Mol.Biol., 18, 2011
1W0T
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HTRF1 DNA-BINDING DOMAIN IN COMPLEX WITH TELOMERIC DNA.
Descriptor:TELOMERIC REPEAT BINDING FACTOR 1, 5'-D(*CP*TP*GP*TP*TP*AP*GP*GP*GP*TP *TP*AP*GP*GP*GP*TP*TP*AP*G)-3', 5'-D(*TP*CP*TP*AP*AP*CP*CP*CP*TP*AP *AP*CP*CP*CP*TP*AP*AP*CP*A)-3'
Authors:Court, R.I., Chapman, L.M., Fairall, L., Rhodes, D.
Deposit date:2004-06-11
Release date:2004-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:How the Human Telomeric Proteins Trf1 and Trf2 Recognize Telomeric DNA: A View from High-Resolution Crystal Structures
Embo Rep., 6, 2005
1W0U
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HTRF2 DNA-BINDING DOMAIN IN COMPLEX WITH TELOMERIC DNA.
Descriptor:TELOMERIC REPEAT BINDING FACTOR 2, 5'-D(*TP*CP*TP*AP*GP*GP*GP*TP*TP*AP *GP*GP*GP*TP*TP*AP*G)-3', 5'-D(*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP *CP*CP*CP*TP*AP*GP*A)-3'
Authors:Court, R.I., Chapman, L.M., Fairall, L., Rhodes, D.
Deposit date:2004-06-11
Release date:2004-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:How the Human Telomeric Proteins Trf1 and Trf2 Recognize Telomeric DNA: A View from High-Resolution Crystal Structures
Embo Rep., 6, 2005
4A69
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STRUCTURE OF HDAC3 BOUND TO COREPRESSOR AND INOSITOL TETRAPHOSPHATE
Descriptor:HISTONE DEACETYLASE 3,, NUCLEAR RECEPTOR COREPRESSOR 2, ZINC ION, ...
Authors:Watson, P.J., Fairall, L., Santos, G.M., Schwabe, J.W.R.
Deposit date:2011-11-01
Release date:2012-01-11
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate.
Nature, 481, 2012
4BKX
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THE STRUCTURE OF HDAC1 IN COMPLEX WITH THE DIMERIC ELM2-SANT DOMAIN OF MTA1 FROM THE NURD COMPLEX
Descriptor:METASTASIS-ASSOCIATED PROTEIN MTA1, HISTONE DEACETYLASE 1, ZINC ION, ...
Authors:Millard, C.J., Watson, P.J., Celardo, I., Gordiyenko, Y., Cowley, S.M., Robinson, C.V., Fairall, L., Schwabe, J.W.R.
Deposit date:2013-04-30
Release date:2013-07-03
Last modified:2013-07-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Class I Hdacs Share a Common Mechanism of Regulation by Inositol Phosphates.
Mol.Cell, 51, 2013
4CP3
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THE STRUCTURE OF BCL6 BTB (POZ) DOMAIN IN COMPLEX WITH THE ANSAMYCIN ANTIBIOTIC RIFABUTIN.
Descriptor:B-CELL LYMPHOMA 6 PROTEIN, RIFABUTIN
Authors:Evans, S.E., Fairall, L., Goult, B.T., Jamieson, A.G., Ferrigno, P.K., Ford, R., Wagner, S.D., Schwabe, J.W.R.
Deposit date:2014-01-31
Release date:2014-03-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Ansamycin Antibiotic, Rifamycin Sv, Inhibits Bcl6 Transcriptional Repression and Forms a Complex with the Bcl6-Btb/Poz Domain.
Plos One, 9, 2014
4D6K
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STRUCTURE OF DNTTIP1 DIMERISATION DOMAIN.
Descriptor:DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1
Authors:Itoh, T., Fairall, L., Schwabe, J.W.R.
Deposit date:2014-11-11
Release date:2015-02-18
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Functional Characterization of a Cell Cycle Associated Hdac1/2 Complex Reveals the Structural Basis for Complex Assembly and Nucleosome Targeting.
Nucleic Acids Res., 43, 2015
5FXY
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STRUCTURE OF THE HUMAN RBBP4:MTA1(464-546) COMPLEX
Descriptor:HISTONE-BINDING PROTEIN RBBP4, METASTASIS-ASSOCIATED PROTEIN MTA1
Authors:Millard, C.J., Varma, N., Fairall, L., Schwabe, J.W.R.
Deposit date:2016-03-03
Release date:2016-05-18
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structure of the core NuRD repression complex provides insights into its interaction with chromatin.
Elife, 5, 2016
2L5G
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CO-ORDINATES AND 1H, 13C AND 15N CHEMICAL SHIFT ASSIGNMENTS FOR THE COMPLEX OF GPS2 53-90 AND SMRT 167-207
Descriptor:G protein pathway suppressor 2, Putative uncharacterized protein NCOR2
Authors:Oberoi, J., Yang, J., Neuhaus, D., Schwabe, J.W.R.
Deposit date:2010-11-01
Release date:2011-02-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Nat.Struct.Mol.Biol., 18, 2011
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