7QDT
Crystal structure of a mutant (P393GX) Thyroid Receptor Alpha ligand binding domain designed to model dominant negative human mutations.
Summary for 7QDT
| Entry DOI | 10.2210/pdb7qdt/pdb |
| Descriptor | Isoform Alpha-1 of Thyroid hormone receptor alpha, 3,5,3'TRIIODOTHYRONINE (3 entities in total) |
| Functional Keywords | nuclear receptor, thyroid hormone, mutation, nuclear protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 27376.87 |
| Authors | Romartinez-Alonso, B.,Fairall, L.,Agostini, M.,Chatterjee, K.,Schwabe, J. (deposition date: 2021-11-30, release date: 2022-01-26, Last modification date: 2024-01-31) |
| Primary citation | Romartinez-Alonso, B.,Agostini, M.,Jones, H.,McLellan, J.,Sood, D.E.,Tomkinson, N.,Marelli, F.,Gentile, I.,Visser, W.E.,Schoenmakers, E.,Fairall, L.,Privalsky, M.,Moran, C.,Persani, L.,Chatterjee, K.,Schwabe, J.W.R. Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone alpha. Mol.Cell.Biol., 42:e0036321-e0036321, 2022 Cited by PubMed: 34871063DOI: 10.1128/MCB.00363-21 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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