7QDT

Crystal structure of a mutant (P393GX) Thyroid Receptor Alpha ligand binding domain designed to model dominant negative human mutations.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue T3 A 401

Chain	Residue
A	PHE218
A	HIS381
A	ARG384
A	HOH502
A	HOH503
A	HOH506
A	ARG228
A	MET259
A	ARG262
A	THR275
A	LEU276
A	SER277
A	GLY290
A	LEU292

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:16781732, ECO:0007744|PDB:2H77, ECO:0007744|PDB:2H79

Chain	Residue	Details
A	ARG228

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:16781732, ECO:0007744|PDB:2H79

Chain	Residue	Details
A	SER277

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