Author results

4JX3
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CRYSTAL STRUCTURE OF PIM1 KINASE
Descriptor:Serine/threonine-protein kinase pim-1
Authors:Lee, S.J., Han, B.G., Cho, J.W., Choi, J.S., Lee, J.K., Song, H.J., Koh, J.S., Lee, B.I.
Deposit date:2013-03-27
Release date:2013-08-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.
Plos One, 8, 2013
4JX7
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CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH INHIBITOR 2-[(TRANS-4-AMINOCYCLOHEXYL)AMINO]-4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE
Descriptor:Serine/threonine-protein kinase pim-1, PIM1 consensus peptide, 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one
Authors:Lee, S.J., Han, B.G., Cho, J.W., Choi, J.S., Lee, J.K., Song, H.J., Koh, J.S., Lee, B.I.
Deposit date:2013-03-27
Release date:2013-08-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.
Plos One, 8, 2013
1GYA
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N-GLYCAN AND POLYPEPTIDE NMR SOLUTION STRUCTURES OF THE ADHESION DOMAIN OF HUMAN CD2
Descriptor:HUMAN CD2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Wyss, D.F., Choi, J.S., Wagner, G.
Deposit date:1995-05-26
Release date:1996-11-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformation and function of the N-linked glycan in the adhesion domain of human CD2.
Science, 269, 1995
4RSS
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CRYSTAL STRUCTURE OF TYROSINE-PROTEIN KINASE SYK WITH AN INHIBITOR
Descriptor:Tyrosine-protein kinase SYK, 1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, B.I., Lee, S.J., Choi, J.-S.
Deposit date:2014-11-11
Release date:2015-10-21
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
4XG2
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CRYSTAL STRUCTURE OF LIGAND-FREE SYK
Descriptor:Tyrosine-protein kinase SYK
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG3
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG4
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, (3R)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl]methyl}pyrrolidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG6
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG7
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(3-methyl-1-{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG8
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(1-{2-[(3-chloro-1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG9
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(1-{2-[(3-chloro-1,2-dimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
5GHV
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1H-pyrrol-3-yl}methyl)azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2016-06-20
Release date:2016-07-06
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
6IJQ
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SOLUTION STRUCTURE OF BCL-XL BOUND TO P73-TAD PEPTIDE
Descriptor:Tumor protein p73, Bcl-2-like protein 1,Bcl-2-like protein 1
Authors:Yoon, M.-K., Ha, J.-H., Lee, M.-S., Chi, S.-W.
Deposit date:2018-10-11
Release date:2018-11-21
Last modified:2019-01-02
Method:SOLUTION NMR
Cite:Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL.
J. Biol. Chem., 293, 2018
5Y5T
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CRYSTAL STRUCTURES OF SPLEEN TYROSINE KINASE IN COMPLEX WITH A NOVEL INHIBITOR
Descriptor:Tyrosine-protein kinase SYK, 2-[[(1S,2S)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6H-pyrido[4,3-d]pyrimidin-5-one
Authors:Lee, S.J., Lee, B.I.
Deposit date:2017-08-09
Release date:2018-06-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors.
Mol. Cells, 41, 2018
5Y5U
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CRYSTAL STRUCTURES OF SPLEEN TYROSINE KINASE IN COMPLEX WITH A NOVEL INHIBITOR
Descriptor:Tyrosine-protein kinase SYK, 4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8H-pyrido[4,3-d]pyrimidin-5-one
Authors:Lee, S.J., Lee, B.I.
Deposit date:2017-08-09
Release date:2018-06-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors.
Mol. Cells, 41, 2018
5CRU
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CRYSTAL STRUCTURE OF THE BRO DOMAIN OF HD-PTP
Descriptor:Tyrosine-protein phosphatase non-receptor type 23
Authors:Lee, J., Ku, B., Kim, S.J.
Deposit date:2015-07-23
Release date:2016-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0
Plos One, 11, 2016
5CRV
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CRYSTAL STRUCTURE OF THE BRO DOMAIN OF HD-PTP IN A COMPLEX WITH THE CORE REGION OF STAM2
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Signal transducing adapter molecule 2, GLYCEROL
Authors:Lee, J., Ku, B., Kim, S.J.
Deposit date:2015-07-23
Release date:2016-02-24
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0
Plos One, 11, 2016