4XG3

Crystal structure of an inhibitor-bound Syk

Summary for 4XG3

• Entry DOI: 10.2210/pdb4xg3/pdb
• Related: 4XG2 4XG4 4XG5 4XG6 4XG7 4XG8 4XG9
• Descriptor: Tyrosine-protein kinase SYK, 4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate (3 entities in total)
• Functional Keywords: syk kinase, inhibitor, spleen tyrosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane : P43405
• Total number of polymer chains: 2
• Total formula weight: 68781.06

Authors

Lee, S.J.,Choi, J.,Han, B.G.,Song, H.,Koh, J.S.,Lee, B.I. (deposition date: 2014-12-30, release date: 2015-12-30, Last modification date: 2023-11-08)

• Primary citation: Lee, S.J.,Choi, J.S.,Han, B.G.,Kim, H.S.,Song, H.J.,Lee, J.,Nam, S.,Goh, S.H.,Kim, J.H.,Koh, J.S.,Lee, B.I.; Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs; Febs J., 283:3613-3625, 2016; PubMed: 27504936; DOI: 10.1111/febs.13831

Experimental method

X-RAY DIFFRACTION (2.3 Å)