5GHV

Crystal structure of an inhibitor-bound Syk

Replaces:  4XG5

Summary for 5GHV

• Entry DOI: 10.2210/pdb5ghv/pdb
• Related: 4XG2 4XG3 4XG4 4XG6 4XG7 4XG8 4XG9
• Descriptor: Tyrosine-protein kinase SYK, 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1H-pyrrol-3-yl}methyl)azetidin-3-ol (3 entities in total)
• Functional Keywords: syk kinase, inhibitor, spleen tyrosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane : P43405
• Total number of polymer chains: 2
• Total formula weight: 68755.16

Authors

Lee, S.J.,Choi, J.,Han, B.G.,Song, H.,Koh, J.S.,Lee, B.I. (deposition date: 2016-06-20, release date: 2016-07-06, Last modification date: 2023-11-08)

• Primary citation: Lee, S.J.,Choi, J.S.,Han, B.G.,Kim, H.S.,Song, H.J.,Lee, J.,Nam, S.,Goh, S.H.,Kim, J.H.,Koh, J.S.,Lee, B.I.; Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs; Febs J., 283:3613-3625, 2016; PubMed: 27504936; DOI: 10.1111/febs.13831

Experimental method

X-RAY DIFFRACTION (2.8 Å)