4XG3

Crystal structure of an inhibitor-bound Syk

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase SYK	polymer	290	33901.0	2	UniProt (P43405) Pfam (PF07714)	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	C, D (A, B)	4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate	non-polymer		489.6	2	Chemie (X3G)
3	E, F (A, B)	water	water		18.0	149	Chemie (HOH)

Sequence modifications

A, B: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Leu 636	-	expression tag
Glu 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag
His 644	-	expression tag
His 645	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67801.9
Non-Polymers*	Number of molecules	2
	Total formula weight	979.1
All*	Total formula weight	68781.1

*Water molecules are not included.