Crystal structure of tyrosine-protein kinase SYK with an inhibitor

Summary for 4RSS

DescriptorTyrosine-protein kinase SYK, 1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol (3 entities in total)
Functional Keywordskinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane  P43405
Total number of polymer chains1
Total molecular weight34318.47
Lee, B.I.,Lee, S.J.,Choi, J.-S. (deposition date: 2014-11-11, release date: 2015-10-21)
Primary citation
Choi, J.S.,Hwang, H.J.,Kim, S.W.,Lee, B.I.,Lee, J.,Song, H.J.,Koh, J.S.,Kim, J.H.,Lee, P.H.
Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 25:4441-4446, 2015
PubMed: 26384287 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2015.09.011
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.258303.0%13.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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