5Y5T

Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor

Summary for 5Y5T

Entry DOI	10.2210/pdb5y5t/pdb
Descriptor	Tyrosine-protein kinase SYK, 2-[[(1S,2S)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6H-pyrido[4,3-d]pyrimidin-5-one (3 entities in total)
Functional Keywords	inhibitor, spleen tyrosine kinase, human kinase, drug discovery, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34644.91
Authors	Lee, S.J.,Lee, B.I. (deposition date: 2017-08-09, release date: 2018-06-27, Last modification date: 2023-11-22)
Primary citation	Lee, S.J.,Choi, J.S.,Bong, S.M.,Hwang, H.J.,Lee, J.,Song, H.J.,Lee, J.,Kim, J.H.,Koh, J.S.,Lee, B.I. Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors. Mol. Cells, 41:545-552, 2018 Cited by PubMed: 29890824 DOI: 10.14348/molcells.2018.2219 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation