5Y5T

Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase SYK	polymer	293	34216.4	1	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	A	2-[[(1S,2S)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6H-pyrido[4,3-d]pyrimidin-5-one	non-polymer		428.5	1	Chemie (8OR)
3		water	water		18.0	162	Chemie (HOH)

Sequence modifications

A: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	expression tag
Ala 354	-	expression tag
Leu 355	-	expression tag
Leu 636	-	expression tag
Glu 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag
His 644	-	expression tag
His 645	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34216.4
Non-Polymers*	Number of molecules	1
	Total formula weight	428.5
All*	Total formula weight	34644.9

*Water molecules are not included.