4XG2

Crystal structure of ligand-free Syk

Summary for 4XG2

• Entry DOI: 10.2210/pdb4xg2/pdb
• Related: 4XG3 4XG4 4XG5 4XG6 4XG7 4XG8 4XG9
• Descriptor: Tyrosine-protein kinase SYK (2 entities in total)
• Functional Keywords: syk kinase, inhibitor, spleen tyrosine kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane : P43405
• Total number of polymer chains: 1
• Total formula weight: 33900.96

Authors

Lee, S.J.,Choi, J.,Han, B.G.,Song, H.,Koh, J.S.,Lee, B.I. (deposition date: 2014-12-30, release date: 2015-12-30, Last modification date: 2023-11-08)

• Primary citation: Lee, S.J.,Choi, J.S.,Han, B.G.,Kim, H.S.,Song, H.J.,Lee, J.,Nam, S.,Goh, S.H.,Kim, J.H.,Koh, J.S.,Lee, B.I.; Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs; Febs J., 283:3613-3625, 2016; PubMed: 27504936; DOI: 10.1111/febs.13831

Experimental method

X-RAY DIFFRACTION (2.21 Å)