5Y5U

Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor

Summary for 5Y5U

Entry DOI	10.2210/pdb5y5u/pdb
Descriptor	Tyrosine-protein kinase SYK, 4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8H-pyrido[4,3-d]pyrimidin-5-one (3 entities in total)
Functional Keywords	inhibitor, spleen tyrosine kinase, human kinase, drug discovery, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	69215.65
Authors	Lee, S.J.,Lee, B.I. (deposition date: 2017-08-09, release date: 2018-06-27, Last modification date: 2023-11-22)
Primary citation	Lee, S.J.,Choi, J.S.,Bong, S.M.,Hwang, H.J.,Lee, J.,Song, H.J.,Lee, J.,Kim, J.H.,Koh, J.S.,Lee, B.I. Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors. Mol. Cells, 41:545-552, 2018 Cited by PubMed: 29890824 DOI: 10.14348/molcells.2018.2219 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation