5Y5U

Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein kinase SYK	polymer	293	34216.4	2	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	A, B	4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8H-pyrido[4,3-d]pyrimidin-5-one	non-polymer		391.4	2	Chemie (8OU)
3		water	water		18.0	67	Chemie (HOH)

Sequence modifications

A, B: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	expression tag
Ala 354	-	expression tag
Leu 355	-	expression tag
Leu 636	-	expression tag
Glu 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag
His 644	-	expression tag
His 645	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68432.8
Non-Polymers*	Number of molecules	2
	Total formula weight	782.9
All*	Total formula weight	69215.6

*Water molecules are not included.