Crystal structure of an inhibitor-bound Syk

Summary for 4XG7

Related4XG2 4XG3 4XG4 4XG5 4XG6 4XG8 4XG9
DescriptorTyrosine-protein kinase SYK, 1-[(3-methyl-1-{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol (3 entities in total)
Functional Keywordssyk kinase, inhibitor, spleen tyrosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight34291.41
Lee, S.J.,Choi, J.,Han, B.G.,Song, H.,Koh, J.S.,Lee, B.I. (deposition date: 2014-12-30, release date: 2015-12-30, Last modification date: 2020-02-05)
Primary citation
Lee, S.J.,Choi, J.S.,Han, B.G.,Kim, H.S.,Song, H.J.,Lee, J.,Nam, S.,Goh, S.H.,Kim, J.H.,Koh, J.S.,Lee, B.I.
Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283:3613-3625, 2016
PubMed: 27504936 (PDB entries with the same primary citation)
DOI: 10.1111/febs.13831
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24410 0.4% 8.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02