4XG7
Crystal structure of an inhibitor-bound Syk
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase SYK | polymer | 290 | 33901.0 | 1 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens (Human) | Spleen tyrosine kinase,p72-Syk |
2 | A | 1-[(3-methyl-1-{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol | non-polymer | 390.4 | 1 | Chemie (X7G) | |||
3 | water | water | 18.0 | 195 | Chemie (HOH) |
Sequence modifications
A: 356 - 635 (UniProt: P43405)
PDB | External Database | Details |
---|---|---|
Leu 636 | - | expression tag |
Glu 637 | - | expression tag |
His 638 | - | expression tag |
His 639 | - | expression tag |
His 640 | - | expression tag |
His 641 | - | expression tag |
His 642 | - | expression tag |
His 643 | - | expression tag |
His 644 | - | expression tag |
His 645 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 33901.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 390.4 | |
All* | Total formula weight | 34291.4 |