Author results

6N13
  • Download 6n13
  • View 6n13
Molmil generated image of 6n13
UBCH7-UB COMPLEX WITH R0RBR PARKIN AND PHOSPHOUBIQUITIN
Descriptor:E3 ubiquitin-protein ligase parkin, ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ...
Authors:Condos, T.E.C., Dunkerley, K.M., Freeman, E.A., Barber, K.R., Aguirre, J.D., Chaugule, V.K., Xiao, Y., Konermann, L., Walden, H., Shaw, G.S.
Deposit date:2018-11-08
Release date:2018-11-28
Last modified:2018-12-12
Method:SOLUTION NMR
Cite:Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
EMBO J., 37, 2018
5C1Z
  • Download 5c1z
  • View 5c1z
Molmil generated image of 5c1z
PARKIN (UBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, SULFATE ION, ...
Authors:kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5C23
  • Download 5c23
  • View 5c23
Molmil generated image of 5c23
PARKIN (S65DUBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, GLYCEROL, ...
Authors:Kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5N2W
  • Download 5n2w
  • View 5n2w
Molmil generated image of 5n2w
WT-PARKIN AND PUB COMPLEX
Descriptor:E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ZINC ION, ...
Authors:Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
5N38
  • Download 5n38
  • View 5n38
Molmil generated image of 5n38
S65DPARKIN AND PUB COMPLEX
Descriptor:E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, DI(HYDROXYETHYL)ETHER, ...
Authors:Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
5NGZ
  • Download 5ngz
  • View 5ngz
Molmil generated image of 5ngz
UBE2T IN COMPLEX WITH FRAGMENT EM04
Descriptor:Ubiquitin-conjugating enzyme E2 T, 1-(1,3-benzothiazol-2-yl)methanamine
Authors:Morreale, F.E., Bortoluzzi, A., Chaugule, V.K., Arkinson, C., Walden, H., Ciulli, A.
Deposit date:2017-03-21
Release date:2017-05-03
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
J. Med. Chem., 60, 2017
5OJJ
  • Download 5ojj
  • View 5ojj
Molmil generated image of 5ojj
CRYSTAL STRUCTURE OF THE ZN-BOUND UBIQUITIN-CONJUGATING ENZYME UBE2T
Descriptor:Ubiquitin-conjugating enzyme E2 T, ACETATE ION, ZINC ION, ...
Authors:Morreale, F.E., Testa, A., Chaugule, V.K., Bortoluzzi, A., Ciulli, A., Walden, H.
Deposit date:2017-07-21
Release date:2017-10-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.
J. Med. Chem., 60, 2017