5OJJ

Crystal structure of the Zn-bound ubiquitin-conjugating enzyme Ube2T

Summary for 5OJJ

Entry DOI	10.2210/pdb5ojj/pdb
Descriptor	Ubiquitin-conjugating enzyme E2 T, ACETATE ION, ZINC ION, ... (5 entities in total)
Functional Keywords	ubiquitin conjugating enzyme, zinc, domain swap, oligomer, ligase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q9NPD8
Total number of polymer chains	6
Total formula weight	107240.64
Authors	Morreale, F.E.,Testa, A.,Chaugule, V.K.,Bortoluzzi, A.,Ciulli, A.,Walden, H. (deposition date: 2017-07-21, release date: 2017-10-04, Last modification date: 2024-01-17)
Primary citation	Morreale, F.E.,Testa, A.,Chaugule, V.K.,Bortoluzzi, A.,Ciulli, A.,Walden, H. Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements. J. Med. Chem., 60:8183-8191, 2017 Cited by PubMed: 28933844 DOI: 10.1021/acs.jmedchem.7b01071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation