7ZH4

USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement)

Summary for 7ZH4

• Entry DOI: 10.2210/pdb7zh4/pdb
• EMDB information: 14719 14720 14721 14722
• Descriptor: Ubiquitin-60S ribosomal protein L40, Ubiquitin carboxyl-terminal hydrolase 1, ZINC ION, ... (5 entities in total)
• Functional Keywords: inhibitor, deubiquitinase, complex, enzyme-substrate, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 97715.28

Authors

Rennie, M.L.,Walden, H. (deposition date: 2022-04-05, release date: 2022-10-12)

• Primary citation: Rennie, M.L.,Arkinson, C.,Chaugule, V.K.,Walden, H.; Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.; Sci Adv, 8:eabq6353-eabq6353, 2022; PubMed: 36170365; DOI: 10.1126/sciadv.abq6353

Experimental method

ELECTRON MICROSCOPY (2.49 Å)