7ZH4
USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement)
Summary for 7ZH4
Entry DOI | 10.2210/pdb7zh4/pdb |
EMDB information | 14719 14720 14721 14722 |
Descriptor | Ubiquitin-60S ribosomal protein L40, Ubiquitin carboxyl-terminal hydrolase 1, ZINC ION, ... (5 entities in total) |
Functional Keywords | inhibitor, deubiquitinase, complex, enzyme-substrate, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 97715.28 |
Authors | Rennie, M.L.,Walden, H. (deposition date: 2022-04-05, release date: 2022-10-12, Last modification date: 2024-07-24) |
Primary citation | Rennie, M.L.,Arkinson, C.,Chaugule, V.K.,Walden, H. Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8:eabq6353-eabq6353, 2022 Cited by PubMed: 36170365DOI: 10.1126/sciadv.abq6353 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.49 Å) |
Structure validation
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