7ZH4

USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C	Ubiquitin-60S ribosomal protein L40	polymer	80	8875.1	1	UniProt (P62987) Pfam (PF00240) In PDB	Homo sapiens (human)	CEP52,Ubiquitin A-52 residue ribosomal protein fusion product 1
2	D	Ubiquitin carboxyl-terminal hydrolase 1	polymer	786	88390.3	1	UniProt (O94782) Pfam (PF00443) In PDB	Homo sapiens (human)	Deubiquitinating enzyme 1,hUBP,Ubiquitin thioesterase 1,Ubiquitin-specific-processing protease 1
3	D	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D	5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine	non-polymer		384.5	1	Chemie (JDA)
5		water	water		18.0	39	Chemie (HOH)

Sequence modifications

C: 1 - 76 (UniProt: P62987)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

D: 1 - 785 (UniProt: O94782)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 90	Cys 90	engineered mutation
Ala 670	Gly 670	engineered mutation
Ala 671	Gly 671	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	97265.4
Non-Polymers*	Number of molecules	2
	Total formula weight	449.9
All*	Total formula weight	97715.3

*Water molecules are not included.