8A9J

Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 without ML323 (consensus reconstruction)

Summary for 8A9J

• Entry DOI: 10.2210/pdb8a9j/pdb
• Related: 7ZH3 7ZH4 8A9K
• EMDB information: 14720 14721 14722 15284
• Descriptor: Fanconi anemia group I protein, Fanconi anemia group D2 protein, Polyubiquitin-C, ... (7 entities in total)
• Functional Keywords: deubiquitinase, complex, enzyme-substrate, inhibitor, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 501070.06

Authors

Rennie, M.L.,Walden, H. (deposition date: 2022-06-28, release date: 2022-10-12)

• Primary citation: Rennie, M.L.,Arkinson, C.,Chaugule, V.K.,Walden, H.; Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.; Sci Adv, 8:eabq6353-eabq6353, 2022; PubMed: 36170365; DOI: 10.1126/sciadv.abq6353

Experimental method

ELECTRON MICROSCOPY (2.8 Å)