8A9K
Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction)
Summary for 8A9K
Entry DOI | 10.2210/pdb8a9k/pdb |
Related | 7ZH3 7ZH4 8A9J |
EMDB information | 14720 14721 14722 |
Descriptor | Fanconi anemia group I protein, Fanconi anemia group D2 protein, Polyubiquitin-C, ... (8 entities in total) |
Functional Keywords | deubiquitinase, complex, enzyme-substrate, inhibitor, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 7 |
Total formula weight | 501454.53 |
Authors | Rennie, M.L.,Walden, H. (deposition date: 2022-06-28, release date: 2022-10-12, Last modification date: 2023-03-01) |
Primary citation | Rennie, M.L.,Arkinson, C.,Chaugule, V.K.,Walden, H. Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8:eabq6353-eabq6353, 2022 Cited by PubMed: 36170365DOI: 10.1126/sciadv.abq6353 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.85 Å) |
Structure validation
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