Author results

3Q48
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA CUPB2 CHAPERONE
Descriptor:Chaperone CupB2
Authors:Cai, X., Wang, R., Filloux, A., Waksman, G., Meng, G.
Deposit date:2010-12-23
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones
Plos One, 6, 2011
4HRV
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CRYSTAL STRUCTURE OF LIPOPROTEIN GNA1162 FROM NEISSERIA MENINGITIDIS
Descriptor:Putative lipoprotein GNA1162
Authors:Lin, Z., Cai, X., Shen, Y.
Deposit date:2012-10-28
Release date:2013-04-24
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure of Neisseria meningitidis lipoprotein GNA1162
Acta Crystallogr.,Sect.F, 69, 2013
1QAC
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CHANGE IN DIMERIZATION MODE BY REMOVAL OF A SINGLE UNSATISFIED POLAR RESIDUE
Descriptor:IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN
Authors:Pokkuluri, P.R., Cai, X., Johnson, G., Stevens, F.J., Schiffer, M.
Deposit date:1999-02-25
Release date:2000-02-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Change in dimerization mode by removal of a single unsatisfied polar residue located at the interface.
Protein Sci., 9, 2000
3TEQ
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CRYSTAL STRUCTURE OF SOAR DOMAIN
Descriptor:Stromal interaction molecule 1, PHOSPHATE ION
Authors:Yang, X., Jin, H., Cai, X., Shen, Y.
Deposit date:2011-08-15
Release date:2012-04-11
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1).
Proc.Natl.Acad.Sci.USA, 109, 2012
3TER
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CRYSTAL STRUCTURE OF SOAR DOMAIN WITH INHIBITION HELIX FROM C. ELEGANS
Descriptor:Mammalian stromal interaction molecule-1
Authors:Yang, X., Jin, H., Cai, X., Shen, Y.
Deposit date:2011-08-15
Release date:2012-04-11
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.551 Å)
Cite:Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1).
Proc.Natl.Acad.Sci.USA, 109, 2012
5XEZ
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody, mAb1, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5XF1
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody mAb1 Heavy chain, Antibody mAb1 Light chain, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
1EEU
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M4L/Y(27D)D/Q89D/T94H MUTANT OF LEN
Descriptor:KAPPA-4 IMMUNOGLOBULIN (LIGHT CHAIN), ISOPROPYL ALCOHOL
Authors:Pokkuluri, P.R., Cai, X., Gu, M., Stevens, F.J., Schiffer, M.
Deposit date:2000-02-03
Release date:2001-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Factors contributing to decreased protein stability when aspartic acid residues are in beta-sheet regions.
Protein Sci., 11, 2002
1EFQ
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Q38D MUTANT OF LEN
Descriptor:KAPPA-4 IMMUNOGLOBULIN (LIGHT CHAIN), URANYL (VI) ION, ZINC ION
Authors:Pokkuluri, P.R., Cai, X., Gu, M., Stevens, F.J., Schiffer, M.
Deposit date:2000-02-09
Release date:2001-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Factors contributing to decreased protein stability when aspartic acid residues are in beta-sheet regions.
Protein Sci., 11, 2002
2J0J
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CRYSTAL STRUCTURE OF A FRAGMENT OF FOCAL ADHESION KINASE CONTAINING THE FERM AND KINASE DOMAINS.
Descriptor:FOCAL ADHESION KINASE 1, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE
Authors:Lietha, D., Cai, X., Li, Y., Schaller, M.D., Eck, M.J.
Deposit date:2006-08-03
Release date:2007-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Autoinhibition of Focal Adhesion Kinase
Cell(Cambridge,Mass.), 129, 2007
2J0K
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CRYSTAL STRUCTURE OF A FRAGMENT OF FOCAL ADHESION KINASE CONTAINING THE FERM AND KINASE DOMAINS.
Descriptor:FOCAL ADHESION KINASE 1, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE
Authors:Lietha, D., Cai, X., Li, Y., Schaller, M.D., Eck, M.J.
Deposit date:2006-08-03
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for the Autoinhibition of Focal Adhesion Kinase.
Cell(Cambridge,Mass.), 129, 2007
2J0L
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CRYSTAL STRUCTURE OF A THE ACTIVE CONFORMATION OF THE KINASE DOMAIN OF FOCAL ADHESION KINASE WITH A PHOSPHORYLATED ACTIVATION LOOP.
Descriptor:FOCAL ADHESION KINASE 1, SULFATE ION, MAGNESIUM ION, ...
Authors:Lietha, D., Cai, X., Li, Y., Schaller, M.D., Eck, M.J.
Deposit date:2006-08-03
Release date:2007-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Autoinhibition of Focal Adhesion Kinase
Cell(Cambridge,Mass.), 129, 2007
2J0M
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CRYSTAL STRUCTURE A TWO-CHAIN COMPLEX BETWEEN THE FERM AND KINASE DOMAINS OF FOCAL ADHESION KINASE.
Descriptor:FOCAL ADHESION KINASE 1, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE
Authors:Lietha, D., Cai, X., Li, Y., Schaller, M.D., Eck, M.J.
Deposit date:2006-08-03
Release date:2007-07-03
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Autoinhibition of Focal Adhesion Kinase.
Cell(Cambridge,Mass.), 129, 2007
5V54
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CRYSTAL STRUCTURE OF 5-HT1B RECEPTOR IN COMPLEX WITH METHIOTHEPIN
Descriptor:5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B, 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine
Authors:Yin, W.C., Zhou, X.E., Yang, D., de Waal, P., Wang, M.T., Dai, A., Cai, X., Huang, C.Y., Liu, P., Yin, Y., Liu, B., Caffrey, M., Melcher, K., Xu, Y., Wang, M.W., Xu, H.E., Jiang, Y.
Deposit date:2017-03-13
Release date:2018-02-07
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist
Cell Discov, 2018
5VEW
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STRUCTURE OF THE HUMAN GLP-1 RECEPTOR COMPLEX WITH PF-06372222
Descriptor:Glucagon-like peptide 1 receptor,Endolysin chimera, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Song, G., Yang, D., Wang, Y., Graaf, C.D., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z.-J., Wang, M.-W., Stevens, R.C.
Deposit date:2017-04-05
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546, 2017
5VEX
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STRUCTURE OF THE HUMAN GLP-1 RECEPTOR COMPLEX WITH NNC0640
Descriptor:Glucagon-like peptide 1 receptor, Endolysin chimera, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide
Authors:Song, G., Yang, D., Wang, Y., Graaf, C.D., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z.-J., Wang, M.-W., Stevens, R.C.
Deposit date:2017-04-05
Release date:2017-05-17
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546, 2017
5YQZ
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STRUCTURE OF THE GLUCAGON RECEPTOR IN COMPLEX WITH A GLUCAGON ANALOGUE
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Glucagon analogue, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhang, H., Qiao, A., Yang, L., VAN EPS, N., Frederiksen, K., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Can, C., He, L., Yang, H., Lau, J., Ernst, O., Hanson, M., Stevens, R., Wang, M., Seedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B.
Deposit date:2017-11-08
Release date:2018-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
6EWS
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SOLUTION STRUCTURE OF RHABDOPEPTIDE NRPS DOCKING DOMAIN KJ12A-NDD
Descriptor:NRPS Kj12A-NDD
Authors:Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A.K., Bode, H.B., Woehnert, J.
Deposit date:2017-11-06
Release date:2018-10-31
Method:SOLUTION NMR
Cite:Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS.
Nat Commun, 9, 2018
6EWT
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SOLUTION STRUCTURE OF RHABDOPEPTIDE NRPS DOCKING DOMAIN KJ12B-NDD
Descriptor:NRPS Kj12B-NDD
Authors:Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A.K., Bode, H.B., Woehnert, J.
Deposit date:2017-11-06
Release date:2018-10-31
Method:SOLUTION NMR
Cite:Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS.
Nat Commun, 9, 2018
6EWU
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SOLUTION STRUCTURE OF RHABDOPEPTIDE NRPS DOCKING DOMAIN KJ12C-NDD
Descriptor:NRPS Kj12C-NDD
Authors:Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A.K., Bode, H.B., Woehnert, J.
Deposit date:2017-11-06
Release date:2018-10-31
Method:SOLID-STATE NMR
Cite:Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS.
Nat Commun, 9, 2018
6EWV
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SOLUTION STRUCTURE OF DOCKING DOMAIN COMPLEX OF RXP NRPS: KJ12C NDD - KJ12B CDD
Descriptor:NRPS Kj12C-NDD, NRPS Kj12B-CDD
Authors:Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A.K., Bode, H.B., Woehnert, J.
Deposit date:2017-11-06
Release date:2018-10-31
Method:SOLUTION NMR
Cite:Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS.
Nat Commun, 9, 2018
5LVE
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STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN
Descriptor:BENCE-JONES PROTEIN LEN, ZINC ION
Authors:Schiffer, M., Huang, D.-B., Chang, C.-H.
Deposit date:1999-02-24
Release date:2000-02-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Change in dimerization mode by removal of a single unsatisfied polar residue located at the interface.
Protein Sci., 9, 2000
5JZV
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THE STRUCTURE OF D77G HCINAP-ADP
Descriptor:Adenylate kinase isoenzyme 6, ADENOSINE-5'-DIPHOSPHATE
Authors:Liu, Y., Yang, Z., Yang, Y., Cai, X., Zheng, X.
Deposit date:2016-05-17
Release date:2016-08-10
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Nat Commun, 7, 2016
4JZR
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STRUCTURE OF PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) WITH INHIBITORS
Descriptor:Egl nine homolog 1, NICKEL (II) ION, 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one, ...
Authors:Ma, Y., Yang, L.
Deposit date:2013-04-03
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors
Bioorg.Med.Chem., 21, 2013
2KNH
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THE SOLUTION STRUCTURE OF THE ETAFH DOMAIN OF AML1-ETO COMPLEXED WITH HEB PEPTIDE
Descriptor:Protein CBFA2T1, Transcription factor 12
Authors:Park, S., Cierpicki, T., Tonelli, M., Bushweller, J.H.
Deposit date:2009-08-25
Release date:2009-10-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
Blood, 113, 2009
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