5VEW

Structure of the human GLP-1 receptor complex with PF-06372222

Summary for 5VEW

• Entry DOI: 10.2210/pdb5vew/pdb
• Related: 5VEX
• Descriptor: Glucagon-like peptide 1 receptor,Endolysin chimera, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (5 entities in total)
• Functional Keywords: gpcr, class b, 7tm domain, treatment of type 2 diabetes, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P43220
• Total number of polymer chains: 2
• Total formula weight: 108627.26

Authors

Song, G.,Yang, D.,Wang, Y.,Graaf, C.D.,Zhou, Q.,Jiang, S.,Liu, K.,Cai, X.,Dai, A.,Lin, G.,Liu, D.,Wu, F.,Wu, Y.,Zhao, S.,Ye, L.,Han, G.W.,Lau, J.,Wu, B.,Hanson, M.A.,Liu, Z.-J.,Wang, M.-W.,Stevens, R.C. (deposition date: 2017-04-05, release date: 2017-05-24, Last modification date: 2023-10-04)

• Primary citation: Song, G.,Yang, D.,Wang, Y.,de Graaf, C.,Zhou, Q.,Jiang, S.,Liu, K.,Cai, X.,Dai, A.,Lin, G.,Liu, D.,Wu, F.,Wu, Y.,Zhao, S.,Ye, L.,Han, G.W.,Lau, J.,Wu, B.,Hanson, M.A.,Liu, Z.J.,Wang, M.W.,Stevens, R.C.; Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.; Nature, 546:312-315, 2017; PubMed: 28514449; DOI: 10.1038/nature22378

Experimental method

X-RAY DIFFRACTION (2.7 Å)