5V54

Crystal structure of 5-HT1B receptor in complex with methiothepin

Summary for 5V54

• Entry DOI: 10.2210/pdb5v54/pdb
• Descriptor: 5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B, 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine (2 entities in total)
• Functional Keywords: 5-hydroxytryptamine, gpcr antagonist, ob1, electron transport
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P28222
• Total number of polymer chains: 2
• Total formula weight: 90643.41

Authors

Yin, W.C.,Zhou, X.E.,Yang, D.,de Waal, P.,Wang, M.T.,Dai, A.,Cai, X.,Huang, C.Y.,Liu, P.,Yin, Y.,Liu, B.,Caffrey, M.,Melcher, K.,Xu, Y.,Wang, M.W.,Xu, H.E.,Jiang, Y. (deposition date: 2017-03-13, release date: 2018-02-07)

• Primary citation: Yin, W.C.,Zhou, X.E.,Yang, D.,De Waal, P.,Wang, M.T.,Dai, A.,Cai, X.,Huang, C.Y.,Liu, P.,Yin, Y.,Liu, B.,Caffrey, M.,Melcher, K.,Xu, Y.,Wang, M.W.,Xu, H.E.,Jiang, Y.; A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist; Cell Discov, 2018

Experimental method

X-RAY DIFFRACTION (3.9 Å)