5V54

Crystal structure of 5-HT1B receptor in complex with methiothepin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004993	molecular_function	G protein-coupled serotonin receptor activity
A	0005506	molecular_function	iron ion binding
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
B	0004930	molecular_function	G protein-coupled receptor activity
B	0004993	molecular_function	G protein-coupled serotonin receptor activity
B	0005506	molecular_function	iron ion binding
B	0005886	cellular_component	plasma membrane
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0009055	molecular_function	electron transfer activity
B	0016020	cellular_component	membrane
B	0020037	molecular_function	heme binding
B	0022900	biological_process	electron transport chain
B	0042597	cellular_component	periplasmic space

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 89F A 1201

Chain	Residue
A	TRP125
A	TRP327
A	PHE330
A	PHE331
A	THR355
A	TYR359
A	LEU126
A	ASP129
A	ILE130
A	CYS133
A	THR134
A	ILE137
A	VAL201
A	THR213

---

site_id	AC2
Number of Residues	12
Details	binding site for residue 89F B 1201

Chain	Residue
B	ASP129
B	ILE130
B	CYS133
B	THR134
B	ILE137
B	THR213
B	TRP327
B	PHE330
B	PHE331
B	SER334
B	THR355
B	TYR359

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwHLCVIALDRYWaI

Chain	Residue	Details
A	ALA135-ILE151

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL50-TYR75
B	VAL50-TYR75

---

site_id	SWS_FT_FI2
Number of Residues	90
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
A	ARG76-ALA84
A	ASP146-ARG165
A	SER372-SER390
B	ARG76-ALA84
B	ASP146-ARG165
B	SER372-SER390

---

site_id	SWS_FT_FI3
Number of Residues	50
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	ASN85-THR110
B	ASN85-THR110

---

site_id	SWS_FT_FI4
Number of Residues	82
Details	TOPO_DOM: Extracellular

Chain	Residue	Details
A	VAL111-ASP123
A	ARG188-HIS205
A	MET337-ALA349
B	VAL111-ASP123
B	ARG188-HIS205
B	MET337-ALA349

---

site_id	SWS_FT_FI5
Number of Residues	42
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	PHE124-LEU145
B	PHE124-LEU145

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA166-TRP187
B	ALA166-TRP187

---

site_id	SWS_FT_FI7
Number of Residues	44
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	ILE206-TYR228
B	ILE206-TYR228

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	LEU316-VAL336
B	LEU316-VAL336

---

site_id	SWS_FT_FI9
Number of Residues	42
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	ILE350-MET371
B	ILE350-MET371

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:23519210, ECO:0007744|PDB:4IAR

Chain	Residue	Details
A	ASP129
A	THR134
A	VAL201
B	ASP129
B	THR134
B	VAL201

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	SITE: Important for species-specific agonist sensitivity

Chain	Residue	Details
A	THR355
B	THR355

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000255

Chain	Residue	Details
A	CYS388
B	CYS388

---