5V54

Crystal structure of 5-HT1B receptor in complex with methiothepin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004993	molecular_function	G protein-coupled serotonin receptor activity
A	0005506	molecular_function	iron ion binding
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
B	0004930	molecular_function	G protein-coupled receptor activity
B	0004993	molecular_function	G protein-coupled serotonin receptor activity
B	0005506	molecular_function	iron ion binding
B	0005886	cellular_component	plasma membrane
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0009055	molecular_function	electron transfer activity
B	0016020	cellular_component	membrane
B	0020037	molecular_function	heme binding
B	0022900	biological_process	electron transport chain

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 89F A 1201

Chain	Residue
A	TRP125
A	TRP327
A	PHE330
A	PHE331
A	THR355
A	TYR359
A	LEU126
A	ASP129
A	ILE130
A	CYS133
A	THR134
A	ILE137
A	VAL201
A	THR213

---

site_id	AC2
Number of Residues	12
Details	binding site for residue 89F B 1201

Chain	Residue
B	ASP129
B	ILE130
B	CYS133
B	THR134
B	ILE137
B	THR213
B	TRP327
B	PHE330
B	PHE331
B	SER334
B	THR355
B	TYR359

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwHLCVIALDRYWaI

Chain	Residue	Details
A	ALA135-ILE151

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29925951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29925951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29925951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	34
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29925951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29925951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29925951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29925951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29925951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29925951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Motif: {"description":"DRY motif; important for ligand-induced conformation changes and signaling","evidences":[{"source":"UniProtKB","id":"P41595","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Motif: {"description":"NPxxY motif; important for ligand-induced conformation changes and signaling","evidences":[{"source":"UniProtKB","id":"P41595","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23519210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IAR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Site: {"description":"Important for species-specific agonist sensitivity","evidences":[{"source":"PubMed","id":"23519210","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---