5V54

Crystal structure of 5-HT1B receptor in complex with methiothepin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B	polymer	395	44965.2	2	UniProt (P28222) Pfam (PF00001)	Homo sapiens (Human)	5-HT1B,S12,Serotonin 1D beta receptor,5-HT-1D-beta,Serotonin receptor 1B
2	C, D (A, B)	1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine	non-polymer		356.5	2	Chemie (89F)

Sequence modifications

A, B: 37 - 239 (UniProt: P28222)

PDB	External Database	Details
Trp 138	Leu 138	engineered mutation

A, B: 1001 - 1105 (PDB: 5V54)
A, B: 1106 - 390 (UniProt: P28222)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	89930.3
Non-Polymers*	Number of molecules	2
	Total formula weight	713.1
All*	Total formula weight	90643.4

*Water molecules are not included.