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5I6C
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THE STRUCTURE OF THE EUKARYOTIC PURINE/H+ SYMPORTER, UAPA, IN COMPLEX WITH XANTHINE
Descriptor:Uric acid-xanthine permease, XANTHINE, DODECYL-BETA-D-MALTOSIDE
Authors:Alguel, Y., Amillis, S., Leung, J., Lambrinidis, G., Capaldi, S., Scull, N.J., Craven, G., Iwata, S., Armstrong, A., Mikros, E., Diallinas, G., Cameron, A.D., Byrne, B.
Deposit date:2016-02-16
Release date:2016-04-27
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.
Nat Commun, 7, 2016
5OO0
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CDK2(WT) COVALENT ADDUCT WITH D28 AT C177
Descriptor:Cyclin-dependent kinase 2, methyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate
Authors:Craven, G., Morgan, R.M.L., Mann, D.J.
Deposit date:2017-08-04
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Angew. Chem. Int. Ed. Engl., 57, 2018
5OO1
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CDK2(F80C, C177A) COVALENT ADDUCT WITH C37 AT F80C
Descriptor:Cyclin-dependent kinase 2, ~{N}-(4-pyrimidin-2-ylphenyl)propanamide
Authors:Craven, G., Morgan, R.M.L., Mann, D.J.
Deposit date:2017-08-04
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-throughput kinetic analysis for target-directed covalent ligand discovery
To be published
5OO3
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CDK2(F80C, C177A) WITH COVALENT LIGAND AT F80C
Descriptor:Cyclin-dependent kinase 2, 1-(4-ethyl-2,3-dihydroquinoxalin-1-yl)propan-1-one
Authors:Craven, G., Morgan, R.M.L., Mann, D.J.
Deposit date:2017-08-05
Release date:2018-08-29
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:High-throughput kinetic analysis for target-directed covalent ligand discovery
To Be Published
5OSJ
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CDK2(WT) WITH COVALENT ADDUCT AT C177
Descriptor:Cyclin-dependent kinase 2, ~{tert}-butyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate
Authors:Craven, G., Morgan, R.M.L., Mann, D.J.
Deposit date:2017-08-17
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Angew. Chem. Int. Ed. Engl., 57, 2018
5OSM
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CDK2(F80C, C177A) WITH COVALENT ADDUCT AT C80
Descriptor:Cyclin-dependent kinase 2, methyl 1-propanoyl-3,4-dihydro-2~{H}-quinoline-6-carboxylate
Authors:Craven, G., Morgan, R.M.L., Mann, D.J.
Deposit date:2017-08-17
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Angew. Chem. Int. Ed. Engl., 57, 2018