5OO3

Cdk2(F80C, C177A) with covalent ligand at F80C

Summary for 5OO3

• Entry DOI: 10.2210/pdb5oo3/pdb
• Related: 5OO0 5OO1
• Descriptor: Cyclin-dependent kinase 2, 1-(4-ethyl-2,3-dihydroquinoxalin-1-yl)propan-1-one (3 entities in total)
• Functional Keywords: covalent inhibitor, cysteine modification, kinase, allosteric inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 34530.14

Authors

Craven, G.,Morgan, R.M.L.,Mann, D.J. (deposition date: 2017-08-05, release date: 2018-08-29, Last modification date: 2024-10-23)

• Primary citation: Craven, G.,Affron, D.P.,Allen, C.E.,Greener, J.G.,Morgan, R.M.L.,Matthies, S.,Armstrong, A.,Mann, D.J.; High-throughput kinetic analysis for target-directed covalent ligand discovery; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.73 Å)