5OO0

Cdk2(WT) covalent adduct with D28 at C177

Summary for 5OO0

Entry DOI	10.2210/pdb5oo0/pdb
Descriptor	Cyclin-dependent kinase 2, methyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate (3 entities in total)
Functional Keywords	covalent inhibitor, cysteine modification, kinase, allosteric inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34636.22
Authors	Craven, G.,Morgan, R.M.L.,Mann, D.J. (deposition date: 2017-08-04, release date: 2018-03-14, Last modification date: 2024-01-17)
Primary citation	Craven, G.B.,Affron, D.P.,Allen, C.E.,Matthies, S.,Greener, J.G.,Morgan, R.M.L.,Tate, E.W.,Armstrong, A.,Mann, D.J. High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery. Angew. Chem. Int. Ed. Engl., 57:5257-5261, 2018 Cited by PubMed: 29480525 DOI: 10.1002/anie.201711825 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation