5OSM

Cdk2(F80C, C177A) with covalent adduct at C80

Summary for 5OSM

Related5OO0 5OO1 5OO3 5OSJ
DescriptorCyclin-dependent kinase 2, methyl 1-propanoyl-3,4-dihydro-2~{H}-quinoline-6-carboxylate (3 entities in total)
Functional Keywordscovalent inhibitor, cysteine modification, kinase, allosteric inhibitor, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Total number of polymer chains1
Total molecular weight34559.14
Authors
Craven, G.,Morgan, R.M.L.,Mann, D.J. (deposition date: 2017-08-17, release date: 2018-03-14, Last modification date: 2018-05-09)
Primary citation
Craven, G.B.,Affron, D.P.,Allen, C.E.,Matthies, S.,Greener, J.G.,Morgan, R.M.L.,Tate, E.W.,Armstrong, A.,Mann, D.J.
High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Angew. Chem. Int. Ed. Engl., 57:5257-5261, 2018
PubMed: 29480525 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201711825
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.77 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.206300.8%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report