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5OO1

Cdk2(F80C, C177A) covalent adduct with C37 at F80C

Summary for 5OO1
Entry DOI10.2210/pdb5oo1/pdb
Related5OO0
DescriptorCyclin-dependent kinase 2, ~{N}-(4-pyrimidin-2-ylphenyl)propanamide (3 entities in total)
Functional Keywordscovalent inhibitor, cysteine modification, kinase, allosteric inhibitor, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight34539.11
Authors
Craven, G.,Morgan, R.M.L.,Mann, D.J. (deposition date: 2017-08-04, release date: 2018-08-29, Last modification date: 2024-11-20)
Primary citationCraven, G.,Affron, D.P.,Allen, C.E.,Greener, J.G.,Morgan, R.M.L.,Matthies, S.,Armstrong, A.,Mann, D.J.
High-throughput kinetic analysis for target-directed covalent ligand discovery
To be published,
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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