Cdk2(WT) with covalent adduct at C177

Summary for 5OSJ

Related5OO1 5OO3 5OO0
DescriptorCyclin-dependent kinase 2, ~{tert}-butyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate (3 entities in total)
Functional Keywordscovalent inhibitor, cysteine modification, kinase, allosteric inhibitor, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Total number of polymer chains1
Total molecular weight34678.3
Craven, G.,Morgan, R.M.L.,Mann, D.J. (deposition date: 2017-08-17, release date: 2018-03-14, Last modification date: 2018-05-09)
Primary citation
Craven, G.B.,Affron, D.P.,Allen, C.E.,Matthies, S.,Greener, J.G.,Morgan, R.M.L.,Tate, E.W.,Armstrong, A.,Mann, D.J.
High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Angew. Chem. Int. Ed. Engl., 57:5257-5261, 2018
PubMed: 29480525 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201711825
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.222301.6%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report