7WYM

Structure of the SARS-COV-2 main protease with 337 inhibitor

Summary for 7WYM

Entry DOI	10.2210/pdb7wym/pdb
Descriptor	3C-like proteinase nsp5, N-methyl-N-[[4-(trifluoromethyl)-1,3-thiazol-2-yl]methyl]prop-2-enamide (3 entities in total)
Functional Keywords	structure of the sars-cov-2 main protease with 337 inhibitor, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	1
Total formula weight	34075.79
Authors	Qin, B.,Hou, P.,Gao, X.,Cui, S. (deposition date: 2022-02-16, release date: 2022-06-22, Last modification date: 2023-11-29)
Primary citation	Qin, B.,Craven, G.B.,Hou, P.,Chesti, J.,Lu, X.,Child, E.S.,Morgan, R.M.L.,Niu, W.,Zhao, L.,Armstrong, A.,Mann, D.J.,Cui, S. Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease. Acta Pharm Sin B, 12:3924-3933, 2022 Cited by PubMed: 35702321 DOI: 10.1016/j.apsb.2022.06.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation