6YL1

Cdk2(F80C) with Covalent Adduct TK37 at F80C

Summary for 6YL1

• Entry DOI: 10.2210/pdb6yl1/pdb
• Descriptor: Cyclin-dependent kinase 2, methyl 4-(cyclopropylmethyl)-1-prop-2-enoyl-2,3-dihydroquinoxaline-6-carboxylate (3 entities in total)
• Functional Keywords: covalent inhibitor, cysteine modification, kinase, allosteric inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 34612.20

Authors

Craven, G.,Morgan, R.M.L.,Mann, D.J. (deposition date: 2020-04-06, release date: 2020-07-22, Last modification date: 2024-01-24)

• Primary citation: Craven, G.B.,Affron, D.P.,Kosel, T.,Wong, T.L.M.,Jukes, Z.H.,Liu, C.T.,Morgan, R.M.L.,Armstrong, A.,Mann, D.J.; Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT).; Chembiochem, 21:3417-3422, 2020; PubMed: 32659037; DOI: 10.1002/cbic.202000457

Experimental method

X-RAY DIFFRACTION (1.66 Å)