Author results

1S26
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STRUCTURE OF ANTHRAX EDEMA FACTOR-CALMODULIN-ALPHA,BETA-METHYLENEADENOSINE 5'-TRIPHOSPHATE COMPLEX REVEALS AN ALTERNATIVE MODE OF ATP BINDING TO THE CATALYTIC SITE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin, YTTERBIUM (III) ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Bohm, A., Tang, W.-J.
Deposit date:2004-01-08
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of anthrax edema factor-calmodulin-adenosine-5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site
Biochem.Biophys.Res.Commun., 317, 2004
1LVC
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 2' DEOXY, 3' ANTHRANILOYL ATP
Descriptor:calmodulin-sensitive adenylate cyclase, calmodulin, YTTERBIUM (III) ION, ...
Authors:Shen, Y., Lee, Y.-S., Soelaiman, S., Bergson, P., Lu, D., Chen, A., Beckingham, K., Grabarek, Z., Mrksich, M., Tang, W.-J.
Deposit date:2002-05-28
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
Embo J., 21, 2002
1K8T
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF)
Descriptor:CALMODULIN-SENSITIVE ADENYLATE CYCLASE, SULFATE ION, NICKEL (II) ION
Authors:Drum, C.L., Yan, S.-Z., Bard, J., Shen, Y.-Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., Tang, W.-J.
Deposit date:2001-10-25
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
Nature, 415, 2002
1K90
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 3' DEOXY-ATP
Descriptor:CALMODULIN-SENSITIVE ADENYLATE CYCLASE, CALMODULIN, YTTERBIUM (III) ION, ...
Authors:Drum, C.L., Yan, S.-Z., Bard, J., Shen, Y.-Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., Tang, W.-J.
Deposit date:2001-10-26
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
1K93
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN
Descriptor:CALMODULIN-SENSITIVE ADENYLATE CYCLASE, CALMODULIN, SULFATE ION, ...
Authors:Drum, C.L., Yan, S.-Z., Bard, J., Shen, Y.-Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., Tang, W.-J.
Deposit date:2001-10-26
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
1Y0V
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND PYROPHOSPHATE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.-J.
Deposit date:2004-11-16
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor
Embo J., 24, 2005
2YPU
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HUMAN INSULIN DEGRADING ENZYME E111Q IN COMPLEX WITH INHIBITOR COMPOUND 41367
Descriptor:INSULIN-DEGRADING ENZYME, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.-J.
Deposit date:2012-11-01
Release date:2012-11-28
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Imidazole-Derived 2-[N-Carbamoylmethyl-Alkylamino]Acetic Acids,Substrate-Dependent Modulators of Insulin-Degrading Enzyme in Amyloid-Beta Hydrolysis
Eur J Med Chem, 79C, 2014
3KBX
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HUMAN MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA L3M_V63M
Descriptor:CCL3, POTASSIUM ION, ACETATE ION
Authors:Guo, Q., Ren, M., Tang, W.-J.
Deposit date:2009-10-20
Release date:2010-10-27
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.652 Å)
Cite:Structural basis for the oligomerization of macrophage inflammatory protein-1 alpha
To be Published
3N56
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME (IDE) IN COMPLEX WITH HUMAN B-TYPE NATRIURETIC PEPTIDE (BNP)
Descriptor:Insulin-degrading enzyme, Natriuretic peptides B, ZINC ION, ...
Authors:Funke, T., Guo, Q., Tang, W.-J.
Deposit date:2010-05-24
Release date:2010-11-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)
To be Published
3N57
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME (IDE) IN COMPLEX WITH HUMAN ATRIAL NATRIURETIC PEPTIDE (ANP)
Descriptor:Insulin-degrading enzyme, Atrial natriuretic factor, ZINC ION
Authors:Funke, T., Guo, Q., Tang, W.-J.
Deposit date:2010-05-24
Release date:2010-11-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)
To be Published
5L2U
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OLIGOMER CRYSTAL STRUCTURE OF CC CHEMOKINE 5 (CCL5)
Descriptor:C-C motif chemokine 5, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Liang, W., Wang, A., Tang, W.-J.
Deposit date:2016-08-02
Release date:2017-08-09
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:High resolution oligomer crystal structure of CC chemokine 5 (CCL5)
To Be Published
2G47
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH AMYLOID-BETA (1-40)
Descriptor:Insulin-degrading enzyme, amyloid protein beta A4, 1,4-DIETHYLENE DIOXIDE
Authors:Shen, Y., Tang, W.-J.
Deposit date:2006-02-21
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G48
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH AMYLIN
Descriptor:Insulin-degrading enzyme, Islet amyloid polypeptide, 1,4-DIETHYLENE DIOXIDE
Authors:Shen, Y., Tang, W.-J.
Deposit date:2006-02-21
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G49
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH GLUCAGON
Descriptor:Insulin-degrading enzyme, glucagon preproprotein, 1,4-DIETHYLENE DIOXIDE
Authors:Shen, Y., Tang, W.-J.
Deposit date:2006-02-21
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G54
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CRYSTAL STRUCTURE OF ZN-BOUND HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH INSULIN B CHAIN
Descriptor:Insulin-degrading enzyme, insulin, ZINC ION, ...
Authors:Shen, Y., Tang, W.-J.
Deposit date:2006-02-22
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G56
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH INSULIN B CHAIN
Descriptor:Insulin-degrading enzyme, Insulin, 1,4-DIETHYLENE DIOXIDE
Authors:Shen, Y., Tang, W.-J.
Deposit date:2006-02-22
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
3E4Z
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH INSULIN-LIKE GROWTH FACTOR II
Descriptor:Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION
Authors:Guo, Q., Manolopoulou, M., Tang, W.-J.
Deposit date:2008-08-12
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
3E50
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH TRANSFORMING GROWTH FACTOR-ALPHA
Descriptor:Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION
Authors:Guo, Q., Manolopoulou, M., Tang, W.-J.
Deposit date:2008-08-12
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
3OFI
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH UBIQUITIN
Descriptor:Insulin-degrading enzyme, Ubiquitin, ZINC ION, ...
Authors:Kalas, V., Ralat, L.A., Tang, W.-J.
Deposit date:2010-08-15
Release date:2010-09-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Ubiquitin is a novel substrate for human insulin-degrading enzyme.
J.Mol.Biol., 406, 2011
4MHE
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CRYSTAL STRUCTURE OF CC-CHEMOKINE 18
Descriptor:C-C motif chemokine 18, ACETATE ION
Authors:Liang, W.G., Tang, W.-J.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
5CMD
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OLIGOMER CRYSTAL STRUCTURE OF CC CHEMOKINE 5 (CCL5)
Descriptor:C-C motif chemokine 5, SULFATE ION
Authors:Liang, W.G., Tang, W.-J.
Deposit date:2015-07-16
Release date:2016-04-13
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (3.086 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
2R6M
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CRYSTAL STRUCTURE OF RAT CK2-BETA SUBUNIT
Descriptor:Casein kinase II subunit beta, ZINC ION
Authors:Shen, Y.
Deposit date:2007-09-06
Release date:2008-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2
CHIN.SCI.BULL., 54, 2009
2R7I
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CRYSTAL STRUCTURE OF CATALYTIC SUBUNIT OF PROTEIN KINASE CK2
Descriptor:Casein kinase II subunit alpha, SULFATE ION
Authors:Shen, Y.
Deposit date:2007-09-08
Release date:2008-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.003 Å)
Cite:Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2
CHIN.SCI.BULL., 54, 2009
1PK0
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CRYSTAL STRUCTURE OF THE EF3-CAM COMPLEXED WITH PMEAPP
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin, YTTERBIUM (III) ION, ...
Authors:Shen, Y., Tang, W.J.
Deposit date:2003-06-04
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Proc.Natl.Acad.Sci.USA, 101, 2004