Author results

1NAW
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ENOLPYRUVYL TRANSFERASE
Descriptor:UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYL-TRANSFERASE, CYCLOHEXYLAMMONIUM ION
Authors:Schoenbrunn, E., Sack, S., Eschenburg, S., Perrakis, A., Krekel, F., Amrhein, N., Mandelkow, E.
Deposit date:1996-07-23
Release date:1997-07-23
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin.
Structure, 4, 1996
2KIN
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KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS
Descriptor:KINESIN, SULFATE ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Sack, S., Muller, J., Kozielski, F., Marx, A., Thormahlen, M., Biou, V., Mandelkow, E.-M., Brady, S.T., Mandelkow, E.
Deposit date:1997-04-28
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of motor and neck domains from rat brain kinesin.
Biochemistry, 36, 1997
3KIN
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KINESIN (DIMERIC) FROM RATTUS NORVEGICUS
Descriptor:KINESIN HEAVY CHAIN, ADENOSINE-5'-DIPHOSPHATE
Authors:Kozielski, F., Sack, S., Marx, A., Thormahlen, M., Schonbrunn, E., Biou, V., Thompson, A., Mandelkow, E.-M., Mandelkow, E.
Deposit date:1997-08-25
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
Cell(Cambridge,Mass.), 91, 1997
1DLG
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CRYSTAL STRUCTURE OF THE C115S ENTEROBACTER CLOACAE MURA IN THE UN-LIGANDED STATE
Descriptor:UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE MURA, PHOSPHATE ION, CYCLOHEXYLAMMONIUM ION
Authors:Schonbrunn, E., Eschenburg, S., Krekel, F., Luger, K., Amrhein, N.
Deposit date:1999-12-09
Release date:2000-04-12
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA.
Biochemistry, 39, 2000
1EYN
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STRUCTURE OF MURA LIGANDED WITH THE EXTRINSIC FLUORESCENCE PROBE ANS
Descriptor:UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE, 8-ANILINO-1-NAPHTHALENE SULFONATE, GLYCEROL
Authors:Schonbrunn, E., Eschenburg, S., Luger, K., Kabsch, W., Amrhein, N.
Deposit date:2000-05-07
Release date:2000-06-09
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA.
Proc.Natl.Acad.Sci.USA, 97, 2000
1EJC
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CRYSTAL STRUCTURE OF UNLIGANDED MURA (TYPE2)
Descriptor:UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYLTRANSFERASE, PHOSPHATE ION, GLYCEROL
Authors:Eschenburg, S., Schonbrunn, E.
Deposit date:2000-03-02
Release date:2000-10-25
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comparative X-ray analysis of the un-liganded fosfomycin-target murA.
Proteins, 40, 2000
1EJD
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CRYSTAL STRUCTURE OF UNLIGANDED MURA (TYPE1)
Descriptor:UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYLTRANSFERASE, PHOSPHATE ION, CYCLOHEXYLAMMONIUM ION
Authors:Eschenburg, S., Schonbrunn, E.
Deposit date:2000-03-02
Release date:2000-10-25
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Comparative X-ray analysis of the un-liganded fosfomycin-target murA.
Proteins, 40, 2000
1G6S
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STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE AND GLYPHOSATE
Descriptor:EPSP SYNTHASE, SHIKIMATE-3-PHOSPHATE, GLYPHOSATE, ...
Authors:Schonbrunn, E., Eschenburg, S., Shuttleworth, W., Schloss, J.V., Amrhein, N., Evans, J.N.S., Kabsch, W.
Deposit date:2000-11-07
Release date:2001-02-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail.
Proc.Natl.Acad.Sci.USA, 98, 2001
1G6T
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STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE
Descriptor:EPSP SYNTHASE, PHOSPHATE ION, SHIKIMATE-3-PHOSPHATE, ...
Authors:Schonbrunn, E., Eschenburg, S., Shuttleworth, W., Schloss, J.V., Amrhein, N., Evans, J.N.S., Kabsch, W.
Deposit date:2000-11-07
Release date:2001-02-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail.
Proc.Natl.Acad.Sci.USA, 98, 2001
1MI4
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GLYPHOSATE INSENSITIVE G96A MUTANT EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE
Descriptor:5-enolpyruvylshikimate-3-phosphate synthase, SHIKIMATE-3-PHOSPHATE, FORMIC ACID
Authors:Eschenburg, S., Healy, M.L., Priestman, M.A., Lushington, G.H., Schonbrunn, E.
Deposit date:2002-08-21
Release date:2002-12-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:How the mutation glycine96 to alanine confers glyphosate insensitivity to 5-enolpyruvyl shikimate-3-phosphate synthase from Escherichia coli.
PLANTA, 216, 2002
1Q36
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EPSP SYNTHASE (ASP313ALA) LIGANDED WITH TETRAHEDRAL REACTION INTERMEDIATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, 5-(1-CARBOXY-1-PHOSPHONOOXY-ETHOXYL)-4-HYDROXY-3-PHOSPHONOOXY-CYCLOHEX-1-ENECARBOXYLIC ACID, FORMIC ACID
Authors:Eschenburg, S., Kabsch, W., Healy, M.L., Schonbrunn, E.
Deposit date:2003-07-28
Release date:2003-12-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A New View of the Mechanisms of UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) and 5-Enolpyruvylshikimate-3-phosphate Synthase (AroA) Derived from X-ray Structures of Their Tetrahedral Reaction Intermediate States.
J.Biol.Chem., 278, 2003
1Q3G
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MURA (ASP305ALA) LIGANDED WITH TETRAHEDRAL REACTION INTERMEDIATE
Descriptor:UDP-N-acetylglucosamine 1-carboxyvinyltransferase, 3'-1-CARBOXY-1-PHOSPHONOOXY-ETHOXY-URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, 1,2-ETHANEDIOL
Authors:Eschenburg, S., Kabsch, W., Healy, M.L., Schonbrunn, E.
Deposit date:2003-07-29
Release date:2003-12-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A New View of the Mechanisms of UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) and 5-Enolpyruvylshikimate-3-phosphate Synthase (AroA) Derived from X-ray Structures of Their Tetrahedral Reaction Intermediate States.
J.Biol.Chem., 278, 2003
1RYW
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C115S MURA LIGANDED WITH REACTION PRODUCTS
Descriptor:UDP-N-acetylglucosamine 1-carboxyvinyltransferase, PHOSPHATE ION, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL) BUTYRIC ACID, ...
Authors:Eschenburg, S., Schonbrunn, E.
Deposit date:2003-12-22
Release date:2004-11-09
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evidence That the Fosfomycin Target Cys115 in UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA) Is Essential for Product Release.
J.Biol.Chem., 280, 2005
1YBG
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MURA INHIBITED BY A DERIVATIVE OF 5-SULFONOXY-ANTHRANILIC ACID
Descriptor:UDP-N-acetylglucosamine 1-carboxyvinyltransferase, N-METHYL-N-{2-[(2-NAPHTHYLSULFONYL)AMINO]-5-[(2-NAPHTHYLSULFONYL)OXY]BENZOYL}-L-ASPARTIC ACID
Authors:Eschenburg, S., Priestman, M.A., Abdul-Latif, F.A., Delachaume, C., Fassy, F., Schonbrunn, E.
Deposit date:2004-12-20
Release date:2005-02-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Novel Inhibitor That Suspends the Induced Fit Mechanism of UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA).
J.Biol.Chem., 280, 2005
1X8R
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EPSPS LIGANDED WITH THE (S)-PHOSPHONATE ANALOG OF THE TETRAHEDRAL REACTION INTERMEDIATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, [3R-[3A,4A,5B(S*)]]-5-(1-CARBOXY-1-PHOSPHONOETHOXY)-4-HYDROXY-3-(PHOSPHONOOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID, FORMIC ACID
Authors:Priestman, M.A., Healy, M.L., Becker, A., Alberg, D.G., Bartlett, P.A., Schonbrunn, E.
Deposit date:2004-08-18
Release date:2005-04-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Interaction of phosphonate analogues of the tetrahedral reaction intermediate with 5-enolpyruvylshikimate-3-phosphate synthase in atomic detail.
Biochemistry, 44, 2005
1X8T
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EPSPS LIGANDED WITH THE (R)-PHOSPHONATE ANALOG OF THE TETRAHEDRAL REACTION INTERMEDIATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, [3R-[3A,4A,5B(R*)]]-5-(1-CARBOXY-1-PHOSPHONOETHOXY)-4-HYDROXY-3-(PHOSPHONOOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID, FORMIC ACID
Authors:Priestman, M.A., Healy, M.L., Becker, A., Alberg, D.G., Bartlett, P.A., Schonbrunn, E.
Deposit date:2004-08-18
Release date:2005-04-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Interaction of phosphonate analogues of the tetrahedral reaction intermediate with 5-enolpyruvylshikimate-3-phosphate synthase in atomic detail.
Biochemistry, 44, 2005
1ZCM
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HUMAN CALPAIN PROTEASE CORE INHIBITED BY ZLLYCH2F
Descriptor:Calpain 1, large [catalytic] subunit, CALCIUM ION, ...
Authors:Li, Q., Hanzlik, R.P., Weaver, R.F., Schonbrunn, E.
Deposit date:2005-04-12
Release date:2006-01-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core
Biochemistry, 45, 2006
2AA9
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EPSP SYNTHASE LIGANDED WITH SHIKIMATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, FORMIC ACID
Authors:Priestman, M.A., Healy, M.L., Funke, T., Becker, A., Schonbrunn, E.
Deposit date:2005-07-13
Release date:2006-02-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate.
Febs Lett., 579, 2005
2GG4
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CP4 EPSP SYNTHASE (UNLIGANDED)
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase
Authors:Schonbrunn, E., Funke, T.
Deposit date:2006-03-23
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular basis for the herbicide resistance of Roundup Ready crops.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GG6
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CP4 EPSP SYNTHASE LIGANDED WITH S3P
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SULFATE ION, SHIKIMATE-3-PHOSPHATE
Authors:Schonbrunn, E., Funke, T.
Deposit date:2006-03-23
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Molecular basis for the herbicide resistance of Roundup Ready crops.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GGA
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CP4 EPSP SYNTHASE LIGANDED WITH S3P AND GLYPHOSATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, GLYPHOSATE
Authors:Schonbrunn, E., Funke, T.
Deposit date:2006-03-23
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis for the herbicide resistance of Roundup Ready crops.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GGD
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CP4 EPSP SYNTHASE ALA100GLY LIGANDED WITH S3P AND GLYPHOSATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, GLYPHOSATE
Authors:Schonbrunn, E., Funke, T.
Deposit date:2006-03-23
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis for the herbicide resistance of Roundup Ready crops.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2QFQ
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E. COLI EPSP SYNTHASE PRO101LEU LIGANDED WITH S3P
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, FORMIC ACID
Authors:Schonbrunn, E., Healy-Fried, M.L.
Deposit date:2007-06-27
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase.
J.Biol.Chem., 282, 2007
2QFS
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E.COLI EPSP SYNTHASE PRO101SER LIGANDED WITH S3P
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, FORMIC ACID
Authors:Schonbrunn, E., Healy-Fried, M.L.
Deposit date:2007-06-28
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase.
J.Biol.Chem., 282, 2007
2QFT
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E.COLI EPSP SYNTHASE PRO101SER LIGANDED WITH S3P AND GLYPHOSATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, GLYPHOSATE, SHIKIMATE-3-PHOSPHATE, ...
Authors:Schonbrunn, E., Healy-Fried, M.L.
Deposit date:2007-06-28
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase.
J.Biol.Chem., 282, 2007