8FP5

CDK2 liganded with ATP and Mg2+

Summary for 8FP5

Entry DOI	10.2210/pdb8fp5/pdb
Descriptor	Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	allosteric, inhibitor, cell cycle, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34570.04
Authors	Schonbrunn, E.,Sun, L. (deposition date: 2023-01-04, release date: 2023-05-31, Last modification date: 2023-10-25)
Primary citation	Faber, E.B.,Sun, L.,Tang, J.,Roberts, E.,Ganeshkumar, S.,Wang, N.,Rasmussen, D.,Majumdar, A.,Hirsch, L.E.,John, K.,Yang, A.,Khalid, H.,Hawkinson, J.E.,Levinson, N.M.,Chennathukuzhi, V.,Harki, D.A.,Schonbrunn, E.,Georg, G.I. Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14:3213-3213, 2023 Cited by PubMed: 37270540 DOI: 10.1038/s41467-023-38732-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation