7UGI

Bromodomain of EP300 liganded with BMS-536924

Summary for 7UGI

• Entry DOI: 10.2210/pdb7ugi/pdb
• Descriptor: Histone acetyltransferase p300, (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ... (5 entities in total)
• Functional Keywords: bromodomain, small molecule ligand, complex, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 29570.61

Authors

Schonbrunn, E.,Bikowitz, M. (deposition date: 2022-03-24, release date: 2023-04-12, Last modification date: 2023-10-25)

• Primary citation: Schonbrunn, E.,Bikowitz, M.; Structural basis of CBP and EP300 interaction with kinase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)