Author results

1AGW
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-25
Release date:1998-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1FGI
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-22
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
2FGI
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1), 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA
Authors:Mohammadi, M., Froum, S., Hamby, J.M., Schroeder, M., Panek, R.L., Lu, G.H., Eliseenkova, A.V., Green, D., Schlessinger, J., Hubbard, S.R.
Deposit date:1998-09-15
Release date:1999-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
EMBO J., 17, 1998
1FGK
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1
Descriptor:FGF RECEPTOR 1
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-02-08
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.
Cell(Cambridge,Mass.), 86, 1996
2P23
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CRYSTAL STRUCTURE OF HUMAN FGF19
Descriptor:Fibroblast growth factor 19
Authors:Mohammadi, M.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
2P39
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CRYSTAL STRUCTURE OF HUMAN FGF23
Descriptor:Fibroblast growth factor 23, SUCROSE OCTASULFATE
Authors:Mohammadi, M.
Deposit date:2007-03-08
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
3HBW
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CRYSTAL STRUCTURE OF HUMAN FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 2A (FHF2A), ALSO REFERRED TO AS FIBROBLAST GROWTH FACTOR 13A (FGF13A)
Descriptor:Fibroblast growth factor 13
Authors:Mohammadi, M.
Deposit date:2009-05-05
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.
J.Biol.Chem., 284, 2009
2FDB
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CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR (FGF)8B IN COMPLEX WITH FGF RECEPTOR (FGFR) 2C
Descriptor:fibroblast growth factor 8 isoform B, Fibroblast growth factor receptor 2
Authors:Mohammadi, M., Olsen, S.K.
Deposit date:2005-12-13
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain
Genes Dev., 20, 2006
5UGL
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 TYROSINE KINASE DOMAIN HARBORING THE D650V ACTIVATING MUTATION
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Mohammadi, M., Chen, H.
Deposit date:2017-01-09
Release date:2017-02-22
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.861 Å)
Cite:Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5UGX
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 2 HARBORING A E565A/D650V DOUBLE GAIN-OF-FUNCTION MUTATION
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Mohammadi, M., Chen, H.
Deposit date:2017-01-10
Release date:2017-02-22
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5UHN
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 2 HARBORING A N549H/E565A DOUBLE GAIN-OF-FUNCTION MUTATION
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Mohammadi, M., Chen, H.
Deposit date:2017-01-11
Release date:2017-02-22
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.909 Å)
Cite:Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5UI0
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 2 HARBORING AN E565A/K659M DOUBLE GAIN-OF-FUNCTION MUTATION
Descriptor:Fibroblast growth factor receptor 2, CITRATE ANION, SULFATE ION, ...
Authors:Mohammadi, M., Chen, H.
Deposit date:2017-01-12
Release date:2017-02-22
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5W21
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CRYSTAL STRUCTURE OF A 1:1:1 FGF23-FGFR1C-AKLOTHO TERNARY COMPLEX
Descriptor:Klotho, Fibroblast growth factor 23, Fibroblast growth factor receptor 1, ...
Authors:Mohammadi, M.
Deposit date:2017-06-05
Release date:2018-01-24
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.
Nature, 553, 2018
5W59
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CRYSTAL STRUCTURE OF A MONOMERIC HUMAN FGF9 IN COMPLEX WITH THE ECTODOMAIN OF HUMAN FGFR1C
Descriptor:Fibroblast growth factor 9, Fibroblast growth factor receptor 1, SULFATE ION
Authors:Mohammadi, M., Ma, J., Liu, Y.
Deposit date:2017-06-14
Release date:2017-08-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization.
Structure, 25, 2017
1Q1U
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CRYSTAL STRUCTURE OF HUMAN FHF1B (FGF12B)
Descriptor:fibroblast growth factor homologous factor 1, SULFATE ION
Authors:Olsen, S.K., Garbi, M., Zampieri, N., Eliseenkova, A.V., Ornitz, D.M., Goldfarb, M., Mohammadi, M.
Deposit date:2003-07-22
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs
J.Biol.Chem., 278, 2003
1NUN
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CRYSTAL STRUCTURE ANALYSIS OF THE FGF10-FGFR2B COMPLEX
Descriptor:Fibroblast growth factor-10, fibroblast growth factor receptor 2 isoform 2, SULFATE ION, ...
Authors:Yeh, B.K., Igarashi, M., Eliseenkova, A.V., Plotnikov, A.N., Sher, I., Ron, D., Aaronson, S.A., Mohammadi, M.
Deposit date:2003-01-31
Release date:2003-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.
Proc.Natl.Acad.Sci.USA, 100, 2003
3F1R
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CRYSTAL STRUCTURE OF FGF20 DIMER
Descriptor:Fibroblast growth factor 20, SULFATE ION
Authors:Kalinina, J., Mohammadi, M.
Deposit date:2008-10-28
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix
Mol.Cell.Biol., 29, 2009
4QQC
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CRYSTAL STRUCTURE OF FGF RECEPTOR (FGFR) 4 KINASE DOMAIN IN COMPLEX WITH FIIN-2, AN IRREVERSIBLE TYROSINE KINASE INHIBITOR CAPABLE OF OVERCOMING FGFR KINASE GATE-KEEPER MUTATIONS
Descriptor:Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, SULFATE ION
Authors:Huang, Z., Mohammadi, M.
Deposit date:2014-06-27
Release date:2014-10-29
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc.Natl.Acad.Sci.USA, 111, 2014
4R6V
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CRYSTAL STRUCTURE OF FGF RECEPTOR (FGFR) 4 KINASE HARBORING THE V550L GATE-KEEPER MUTATION IN COMPLEX WITH FIIN-3, AN IRREVERSIBLE TYROSINE KINASE INHIBITOR CAPABLE OF OVERCOMING FGFR KINASE GATE-KEEPER MUTATIONS
Descriptor:Fibroblast growth factor receptor 4, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide, SULFATE ION
Authors:Huang, Z., Mohammadi, M.
Deposit date:2014-08-26
Release date:2014-10-29
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.353 Å)
Cite:Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc.Natl.Acad.Sci.USA, 111, 2014
1CVS
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CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX
Descriptor:FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION
Authors:Plotnikov, A.N., Schlessinger, J., Hubbard, S.R., Mohammadi, M.
Deposit date:1999-08-24
Release date:2000-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for FGF receptor dimerization and activation.
Cell(Cambridge,Mass.), 98, 1999
1EV2
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CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION
Authors:Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Deposit date:2000-04-19
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1EVT
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CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION
Authors:Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Deposit date:2000-04-20
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1FQ9
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CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Descriptor:FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, ...
Authors:Schlessinger, J., Plotnikov, A.N., Ibrahimi, O.A., Eliseenkova, A.V., Yeh, B.K., Yayon, A., Linhardt, R.J., Mohammadi, M.
Deposit date:2000-09-04
Release date:2000-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Mol.Cell, 6, 2000
1IHK
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CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)
Descriptor:GLIA-ACTIVATING FACTOR, PHOSPHATE ION
Authors:Plotnikov, A.N., Eliseenkova, A.V., Ibrahimi, O.A., Lemmon, M.A., Mohammadi, M.
Deposit date:2001-04-19
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.
J.Biol.Chem., 276, 2001
1II4
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CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Descriptor:HEPARIN-BINDING GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 2
Authors:Ibrahimi, O.A., Eliseenkova, A.V., Plotnikov, A.N., Ornitz, D.M., Mohammadi, M.
Deposit date:2001-04-20
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proc.Natl.Acad.Sci.USA, 98, 2001
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