Author results

1YPV
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STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS
Descriptor:Thymidylate synthase, PHOSPHATE ION
Authors:Lovelace, L.L., Minor, W., Lebioda, L.
Deposit date:2005-01-31
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of human thymidylate synthase under low-salt conditions.
Acta Crystallogr.,Sect.D, 61, 2005
2ONB
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HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS WITH PDPA BOUND
Descriptor:Thymidylate synthetase, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Lovelace, L.L., Gibson, L.M., Lebioda, L.
Deposit date:2007-01-23
Release date:2007-04-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors
Biochemistry, 46, 2007
2QOS
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CRYSTAL STRUCTURE OF COMPLEMENT PROTEIN C8 IN COMPLEX WITH A PEPTIDE CONTAINING THE C8 BINDING SITE ON C8
Descriptor:Complement component 8, gamma polypeptide, Complement component C8 alpha chain
Authors:Lovelace, L.L., Chiswell, B., Slade, D.J., Sodetz, J.M., Lebioda, L.
Deposit date:2007-07-20
Release date:2007-10-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: Implications for C8gamma ligand binding.
Mol.Immunol., 45, 2008
3EGY
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CRYSTAL STRUCTURE OF HUMAN THYMIDYALTE SYNTHASE A191K WITH LOOP 181-197 STABILIZED IN THE INACTIVE CONFORMATION
Descriptor:Thymidylate synthase, SULFATE ION, 1,2-ETHANEDIOL
Authors:Lovelace, L.L., Gibson, L.M., Johnson, S.R., Berger, S.H., Lebioda, L.
Deposit date:2008-09-11
Release date:2009-08-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation.
Protein Sci., 18, 2009
3EHI
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CRYSTAL STRUCTURE OF HUMAN THYMIDYALTE SYNTHASE M190K WITH LOOP 181-197 STABILIZED IN THE INACTIVE CONFORMATION
Descriptor:Thymidylate synthase, SULFATE ION, 1,2-ETHANEDIOL
Authors:Lovelace, L.L., Gibson, L.M., Johnson, S.R., Berger, S.H., Lebioda, L.
Deposit date:2008-09-12
Release date:2009-08-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation.
Protein Sci., 18, 2009
3OJY
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT COMPONENT C8
Descriptor:Complement component C8 alpha chain, Complement component C8 beta chain, Complement component C8 gamma chain, ...
Authors:Lovelace, L.L., Cooper, C.L., Sodetz, J.M., Lebioda, L.
Deposit date:2010-08-23
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.
J.Biol.Chem., 286, 2011
2RD7
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HUMAN COMPLEMENT MEMBRANE ATTACK PROTEINS SHARE A COMMON FOLD WITH BACTERIAL CYTOLYSINS
Descriptor:Complement component C8 alpha chain, Complement component C8 gamma chain, CHLORIDE ION
Authors:Slade, D.J., Lovelace, L.L., Chruszcz, M., Minor, W., Lebioda, L., Sodetz, J.M.
Deposit date:2007-09-21
Release date:2008-05-27
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.
J. Biol. Chem., 286, 2011
2AKM
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FLUORIDE INHIBITION OF ENOLASE: CRYSTAL STRUCTURE OF THE INHIBITORY COMPLEX
Descriptor:Gamma enolase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Qin, J., Chai, G., Brewer, J.M., Lovelace, L.L.
Deposit date:2005-08-03
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Fluoride inhibition of enolase: crystal structure and thermodynamics
Biochemistry, 45, 2006
2AKZ
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FLUORIDE INHIBITION OF ENOLASE: CRYSTAL STRUCTURE OF THE INHIBITORY COMPLEX
Descriptor:Gamma enolase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Qin, J., Chai, G., Brewer, J.M., Lovelace, L.L.
Deposit date:2005-08-04
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Fluoride inhibition of enolase: crystal structure and thermodynamics
Biochemistry, 45, 2006
2EVK
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THE STRUCTURES OF THIOLATE- AND CARBOXYLATE-LIGATED FERRIC H93G MYOGLOBIN: MODELS FOR CYTOCHROME P450 AND FOR OXYANION-BOUND HEME PROTEINS
Descriptor:Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ACETIC ACID
Authors:Qin, J., Perera, R., Lovelace, L.L., Dawson, J.H., Lebioda, L.
Deposit date:2005-10-31
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structures of thiolate- and carboxylate-ligated ferric H93G myoglobin: models for cytochrome P450 and for oxyanion-bound heme proteins.
Biochemistry, 45, 2006
2EVP
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THE STRUCTURES OF THIOLATE- AND CARBOXYLATE-LIGATED FERRIC H93G MYOGLOBIN: MODELS FOR CYTOCHROME P450 AND FOR OXYANION-BOUND HEME PROTEINS
Descriptor:Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, BETA-MERCAPTOETHANOL
Authors:Qin, J., Perera, R., Lovelace, L.L., Dawson, J.H., Lebioda, L.
Deposit date:2005-10-31
Release date:2006-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of Thiolate- and Carboxylate-Ligated Ferric H93G Myoglobin: Models for Cytochrome P450 and for Oxyanion-Bound Heme Proteins(,).
Biochemistry, 45, 2006
2OVA
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X-RAY STRUCTURE OF HUMAN COMPLEMENT PROTEIN C8GAMMA Y83W MUTANT
Descriptor:Complement component 8, gamma polypeptide
Authors:Chiswell, B., Lovelace, L.L., Brannen, C., Ortlund, E.A., Lebioda, L., Sodetz, J.M.
Deposit date:2007-02-13
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural features of the ligand binding site on human complement protein C8gamma: A member of the lipocalin family
Biochim.Biophys.Acta, 1774, 2007
2OVD
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT PROTEIN C8GAMMA WITH LAURATE
Descriptor:Complement component 8, gamma polypeptide, LAURIC ACID
Authors:Chiswell, B., Lovelace, L.L., Brannen, C., Ortlund, E.A., Lebioda, L., Sodetz, J.M.
Deposit date:2007-02-13
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural features of the ligand binding site on human complement protein C8gamma: A member of the lipocalin family
Biochim.Biophys.Acta, 1774, 2007
2OVE
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN COMPLEMENT PROTEIN C8GAMMA
Descriptor:Complement component 8, gamma polypeptide
Authors:Chiswell, B., Lovelace, L.L., Brannen, C., Ortlund, E.A., Lebioda, L., Sodetz, J.M.
Deposit date:2007-02-13
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural features of the ligand binding site on human complement protein C8gamma: A member of the lipocalin family
Biochim.Biophys.Acta, 1774, 2007
2R8U
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STRUCTURE OF FRAGMENT OF HUMAN END-BINDING PROTEIN 1 (EB1) CONTAINING THE N-TERMINAL DOMAIN AT 1.35 A RESOLUTION
Descriptor:Microtubule-associated protein RP/EB family member 1, MOLYBDATE ION
Authors:Huang, X., Lovelace, L.L., Smith, D., Lebioda, L.
Deposit date:2007-09-11
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of fragment of human end-binding protein 1 (EB1) containing the N-terminal domain at 1.35 A resolution
To be Published
2RD8
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HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195
Descriptor:Thymidylate synthase, BETA-MERCAPTOETHANOL, PHOSPHATE ION
Authors:Gibson, L.M., Lovelace, L.L., Lebioda, L.
Deposit date:2007-09-21
Release date:2008-05-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The R163K Mutant of Human Thymidylate Synthase Is Stabilized in an Active Conformation: Structural Asymmetry and Reactivity of Cysteine 195.
Biochemistry, 47, 2008
2RDA
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HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195
Descriptor:Thymidylate synthase, PHOSPHATE ION, BETA-MERCAPTOETHANOL
Authors:Gibson, L.M., Lovelace, L.L., Lebioda, L.
Deposit date:2007-09-21
Release date:2008-06-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195.
Biochemistry, 47, 2008
3EAW
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REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY
Descriptor:Thymidylate synthase, SULFATE ION, 1,2-ETHANEDIOL
Authors:Huang, X., Gibson, L.M., Bell, B.J., Lovelace, L.L., Pena, M.M., Berger, F.G., Berger, S.H.
Deposit date:2008-08-26
Release date:2010-03-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
Biochemistry, 49, 2010
3EBU
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REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY
Descriptor:Thymidylate synthase, SULFATE ION, 1,2-ETHANEDIOL
Authors:Huang, X., Gibson, L.M., Bell, B.J., Lovelace, L.L., Pena, M.M., Berger, F.G., Berger, S.H.
Deposit date:2008-08-28
Release date:2010-03-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
Biochemistry, 49, 2010
3ED7
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REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY
Descriptor:Thymidylate synthase, SULFATE ION
Authors:Huang, X., Gibson, L.M., Bell, B.J., Lovelace, L.L., Pena, M.M., Berger, F.G., Berger, S.H.
Deposit date:2008-09-02
Release date:2010-03-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
Biochemistry, 49, 2010
3EDW
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REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY
Descriptor:Thymidylate synthase, SULFATE ION
Authors:Huang, X., Gibson, L.M., Bell, B.J., Lovelace, L.L., Pena, M.M., Berger, F.G., Berger, S.H.
Deposit date:2008-09-03
Release date:2010-03-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
Biochemistry, 49, 2010
3EF9
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REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY
Descriptor:Thymidylate synthase, SULFATE ION
Authors:Huang, X., Gibson, L.M., Bell, B.J., Lovelace, L.L., Pena, M.M., Berger, F.G., Berger, S.H.
Deposit date:2008-09-08
Release date:2010-03-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
Biochemistry, 49, 2010
3EJL
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REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY
Descriptor:Thymidylate synthase, PHOSPHATE ION, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE
Authors:Huang, X., Gibson, L.M., Bell, B.J., Lovelace, L.L., Pena, M.M., Berger, F.G., Berger, S.H.
Deposit date:2008-09-18
Release date:2010-03-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
Biochemistry, 49, 2010
3GG5
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REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY
Descriptor:Thymidylate synthase, SULFATE ION, PHOSPHATE ION
Authors:Huang, X., Gibson, L.M., Bell, B.J., Lovelace, L.L., Lebioda, L.
Deposit date:2009-02-27
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
Biochemistry, 49, 2010
3GH0
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REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY
Descriptor:Thymidylate synthase, SULFATE ION
Authors:Huang, X., Gibson, L.M., Bell, B.J., Lovelace, L.L., Lebioda, L.
Deposit date:2009-03-02
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
Biochemistry, 49, 2010
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