3OB7

Human Thymidylate Synthase R163K with Cys 195 covalently modified by Glutathione

Summary for 3OB7

• Entry DOI: 10.2210/pdb3ob7/pdb
• Related: 3H9K 3HB8
• Descriptor: Thymidylate synthase, GLUTATHIONE, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: methyltransferase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P04818
• Total number of polymer chains: 5
• Total formula weight: 179574.19

Authors

Gibson, L.M.,Celeste, L.R.,Lovelace, L.L.,Lebioda, L. (deposition date: 2010-08-06, release date: 2010-12-22, Last modification date: 2023-09-06)

• Primary citation: Gibson, L.M.,Celeste, L.R.,Lovelace, L.L.,Lebioda, L.; Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding.; Acta Crystallogr.,Sect.D, 67:60-66, 2011; PubMed: 21206062; DOI: 10.1107/S0907444910044732

Experimental method

X-RAY DIFFRACTION (2.75 Å)