2ONB
Human Thymidylate Synthase at low salt conditions with PDPA bound
Summary for 2ONB
Entry DOI | 10.2210/pdb2onb/pdb |
Related | 1YPV |
Descriptor | Thymidylate synthetase, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | diphosphonic acid, fdump, zd9331, heteroinhibition, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 36429.59 |
Authors | Lovelace, L.L.,Gibson, L.M.,Lebioda, L. (deposition date: 2007-01-23, release date: 2007-04-10, Last modification date: 2023-08-30) |
Primary citation | Lovelace, L.L.,Gibson, L.M.,Lebioda, L. Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors Biochemistry, 46:2823-2830, 2007 Cited by PubMed: 17297914DOI: 10.1021/bi061309j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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