3HB8

Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry

Summary for 3HB8

• Entry DOI: 10.2210/pdb3hb8/pdb
• Related: 1HVY 1HW3 2RD8 2RDA 3H9K 3OB7
• Descriptor: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: transferase, methyl transferase, methyltransferase, nucleotide biosynthesis
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P04818
• Total number of polymer chains: 5
• Total formula weight: 179975.32

Authors

Gibson, L.M.,Lovelace, L.L.,Lebioda, L. (deposition date: 2009-05-04, release date: 2010-05-26, Last modification date: 2024-02-21)

• Primary citation: Gibson, L.M.,Celeste, L.R.,Lovelace, L.L.,Lebioda, L.; Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding.; Acta Crystallogr.,Sect.D, 67:60-66, 2011; PubMed: 21206062; DOI: 10.1107/S0907444910044732

Experimental method

X-RAY DIFFRACTION (2.74 Å)