3HB8
Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Thymidylate synthase | polymer | 313 | 35734.9 | 5 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (human) | TSase, TS |
| 2 | F, J, K (A, C, D) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 3 | Chemie (UMP) | |||
| 3 | G, I, M (A, B, E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | H, L (B, D) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | N, O, P, Q, R (A, B, C, D, E) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Lys 163 | Arg 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 178674.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1300.7 | |
| All* | Total formula weight | 179975.3 |
