1HVY
Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation
Summary for 1HVY
| Entry DOI | 10.2210/pdb1hvy/pdb |
| Descriptor | THYMIDYLATE SYNTHASE, TOMUDEX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | tomudex, raltitrexed, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus : P04818 |
| Total number of polymer chains | 4 |
| Total formula weight | 135827.09 |
| Authors | Phan, J.,Koli, S.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L. (deposition date: 2001-01-08, release date: 2001-01-31, Last modification date: 2022-04-13) |
| Primary citation | Phan, J.,Koli, S.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L. Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug Biochemistry, 40:1897-1902, 2001 Cited by PubMed: 11329255DOI: 10.1021/bi002413i PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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