1HVY
Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | THYMIDYLATE SYNTHASE | polymer | 288 | 33112.0 | 4 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (human) | |
| 2 | A, B, C, D | TOMUDEX | non-polymer | 458.5 | 4 | Chemie (D16) | |||
| 3 | A, B, C, D | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 4 | Chemie (UMP) | |||
| 4 | A, B, C, D | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 4 | Chemie (BME) | |||
| 5 | water | water | 18.0 | 596 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 26 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Cme 43 | Cys 42 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 132447.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3379.2 | |
| All* | Total formula weight | 135827.1 |
