2RDA
Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195
Summary for 2RDA
Entry DOI | 10.2210/pdb2rda/pdb |
Related | 1HVY 2RD8 |
Descriptor | Thymidylate synthase, PHOSPHATE ION, BETA-MERCAPTOETHANOL, ... (4 entities in total) |
Functional Keywords | methyl transferase, asymmetric, methyltransferase, nucleotide biosynthesis, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P04818 |
Total number of polymer chains | 6 |
Total formula weight | 215040.68 |
Authors | Gibson, L.M.,Lovelace, L.L.,Lebioda, L. (deposition date: 2007-09-21, release date: 2008-06-10, Last modification date: 2023-08-30) |
Primary citation | Gibson, L.M.,Lovelace, L.L.,Lebioda, L. The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195. Biochemistry, 47:4636-4643, 2008 Cited by PubMed: 18370400DOI: 10.1021/bi7019386 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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